Functional and energetic consequences of chronic myocardial creatine depletion by beta-guanidinopropionate in perfused hearts and in intact rats.

Functional and energetic consequences of chronic myocardial creatine depletion by beta-guanidinopropionate in perfused hearts and in intact rats.

Oral feeding with the creatine analogue beta-guanidinopropionate (beta-GP) reduces myocardial phosphocreatine and creatine concentrations by about 80%in vitro, this is accompanied by reduced contractile performance. We hypothesized, thus, that beta-GP feeding leads to hemodynamic changes in vivo cha...

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Dettagli Bibliografici
Autori principali:	Neubauer, S, Hu, K, Horn, M, Remkes, H, Hoffmann, K, Schmidt, C, Schmidt, T, Schnackerz, K, Ertl, G
Natura:	Journal article
Lingua:	English
Pubblicazione:	1999

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