Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates
The reduction of C(6)-acyl bicyclic tetramic acids has been achieved with complete diastereoselectivity via catalytic hydrogenation using PtO2. The resulting pyroglutamates had potent antibacterial and anticancer properties and will allow the preparation of simple mimics of pyroglutamate-containing...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Royal Society of Chemistry
2018
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| _version_ | 1797079284487028736 |
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| author | Josa-Culleré, L Christensen, K Moloney, M |
| author_facet | Josa-Culleré, L Christensen, K Moloney, M |
| author_sort | Josa-Culleré, L |
| collection | OXFORD |
| description | The reduction of C(6)-acyl bicyclic tetramic acids has been achieved with complete diastereoselectivity via catalytic hydrogenation using PtO2. The resulting pyroglutamates had potent antibacterial and anticancer properties and will allow the preparation of simple mimics of pyroglutamate-containing natural products. |
| first_indexed | 2024-03-07T00:43:37Z |
| format | Journal article |
| id | oxford-uuid:83e3301e-2784-4de6-889c-b9c29d7d12fb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:43:37Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:83e3301e-2784-4de6-889c-b9c29d7d12fb2022-03-26T21:47:20ZDiastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamatesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83e3301e-2784-4de6-889c-b9c29d7d12fbEnglishSymplectic Elements at OxfordRoyal Society of Chemistry2018Josa-Culleré, LChristensen, KMoloney, MThe reduction of C(6)-acyl bicyclic tetramic acids has been achieved with complete diastereoselectivity via catalytic hydrogenation using PtO2. The resulting pyroglutamates had potent antibacterial and anticancer properties and will allow the preparation of simple mimics of pyroglutamate-containing natural products. |
| spellingShingle | Josa-Culleré, L Christensen, K Moloney, M Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates |
| title | Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates |
| title_full | Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates |
| title_fullStr | Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates |
| title_full_unstemmed | Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates |
| title_short | Diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates |
| title_sort | diastereoselective reduction of the tricarbonyl moiety in bicyclic tetramates giving pyroglutamates |
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