Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis.
There is much evidence that T cells may be activated via mechanisms that act independently of direct TCR ligation. Despite this, the question of whether such forms of bystander T cell activation occur during immune responses is hotly debated. To address some outstanding questions, we set up an in vi...
| Үндсэн зохиолчид: | , , , , , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
2009
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| _version_ | 1826282434367324160 |
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| author | Bangs, S Baban, D Cattan, H Li, C Mcmichael, A Xu, X |
| author_facet | Bangs, S Baban, D Cattan, H Li, C Mcmichael, A Xu, X |
| author_sort | Bangs, S |
| collection | OXFORD |
| description | There is much evidence that T cells may be activated via mechanisms that act independently of direct TCR ligation. Despite this, the question of whether such forms of bystander T cell activation occur during immune responses is hotly debated. To address some outstanding questions, we set up an in vitro system within which to analyze bystander T cell activation in human T cells, in the absence of the possibility for TCR cross-reactivity. In addition, we have investigated the genetic, phenotypic, and functional characteristics of bystander-activated T cells. In this study, we show that bystander T cell activation is, indeed, observed during a specific immune response, and that it occurs preferentially among CD4(+) memory T cells. Furthermore, bystander-activated T cells display a distinct gene expression profile. The mechanism for bystander T cell activation involves soluble factors, and the outcome is an elevated level of apoptosis. This may provide an explanation for the attrition of T cell memory pools of heterologous specificity during immune responses to pathogens such as viruses. |
| first_indexed | 2024-03-07T00:43:48Z |
| format | Journal article |
| id | oxford-uuid:83f3231f-b574-42fa-b643-d40f8ef38e3f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:43:48Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:83f3231f-b574-42fa-b643-d40f8ef38e3f2022-03-26T21:47:44ZHuman CD4+ memory T cells are preferential targets for bystander activation and apoptosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83f3231f-b574-42fa-b643-d40f8ef38e3fEnglishSymplectic Elements at Oxford2009Bangs, SBaban, DCattan, HLi, CMcmichael, AXu, XThere is much evidence that T cells may be activated via mechanisms that act independently of direct TCR ligation. Despite this, the question of whether such forms of bystander T cell activation occur during immune responses is hotly debated. To address some outstanding questions, we set up an in vitro system within which to analyze bystander T cell activation in human T cells, in the absence of the possibility for TCR cross-reactivity. In addition, we have investigated the genetic, phenotypic, and functional characteristics of bystander-activated T cells. In this study, we show that bystander T cell activation is, indeed, observed during a specific immune response, and that it occurs preferentially among CD4(+) memory T cells. Furthermore, bystander-activated T cells display a distinct gene expression profile. The mechanism for bystander T cell activation involves soluble factors, and the outcome is an elevated level of apoptosis. This may provide an explanation for the attrition of T cell memory pools of heterologous specificity during immune responses to pathogens such as viruses. |
| spellingShingle | Bangs, S Baban, D Cattan, H Li, C Mcmichael, A Xu, X Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. |
| title | Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. |
| title_full | Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. |
| title_fullStr | Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. |
| title_full_unstemmed | Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. |
| title_short | Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. |
| title_sort | human cd4 memory t cells are preferential targets for bystander activation and apoptosis |
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