Impact of host responses on control of hepatitis C virus infection in Chinese blood donors
A study was undertaken to explore the molecular mechanisms underlying control of HCV infection in blood donors in China. Factors including clinical information, anti-HCV reactivity (S/CO), IFN-α and IFN-γ, viral loads and genotypes were correlated with 160 index plasma samples at three statuses of 4...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1826282438798606336 |
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| author | Li, T Chen, Z Zeng, J Zhang, J Wang, W Zhang, L Zheng, X Shuai, L Klenerman, P Allain, J Li, C |
| author_facet | Li, T Chen, Z Zeng, J Zhang, J Wang, W Zhang, L Zheng, X Shuai, L Klenerman, P Allain, J Li, C |
| author_sort | Li, T |
| collection | OXFORD |
| description | A study was undertaken to explore the molecular mechanisms underlying control of HCV infection in blood donors in China. Factors including clinical information, anti-HCV reactivity (S/CO), IFN-α and IFN-γ, viral loads and genotypes were correlated with 160 index plasma samples at three statuses of 45 recovered, 76 chronic or 39 false positive anti-HCV reactive blood donors. The spontaneous recovery rate was 37.2%. Viral loads of 76 HCV plasmas ranged between 59.8IU/ml and 2.43×10 6IU/ml (median 3.67×10 4IU/ml). Genotypes 1, 2, 3 and 6 of 63 HCV strains were identified phylogenetically. Recovered donors were significantly younger (p=0.002) and had lower level IFN-γ (p=0.001) than chronically HCV infected donors. Circulating levels of IFN-α and IFN-γ were higher in those with low viral load and were low in middle or high viral load samples. The ratio of IFN-α to IFN-γ (IFN-α/γ) was significantly positively correlated with viral load (p=0.037), and viral load was inversely correlated with IFN-γ in chronic HCV infection regardless of genotype. The study revealed clearly different relationships between IFN-α and IFN-γ in relation to viral load in HCV. A novel measure of IFN-α/γ ratio could be a new approach to evaluate long term outcome of HCV infection. © 2011 Elsevier Inc. |
| first_indexed | 2024-03-07T00:43:52Z |
| format | Journal article |
| id | oxford-uuid:83f79c30-2567-4d4f-beb8-a599e9333608 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:43:52Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:83f79c30-2567-4d4f-beb8-a599e93336082022-03-26T21:47:48ZImpact of host responses on control of hepatitis C virus infection in Chinese blood donorsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:83f79c30-2567-4d4f-beb8-a599e9333608EnglishSymplectic Elements at Oxford2011Li, TChen, ZZeng, JZhang, JWang, WZhang, LZheng, XShuai, LKlenerman, PAllain, JLi, CA study was undertaken to explore the molecular mechanisms underlying control of HCV infection in blood donors in China. Factors including clinical information, anti-HCV reactivity (S/CO), IFN-α and IFN-γ, viral loads and genotypes were correlated with 160 index plasma samples at three statuses of 45 recovered, 76 chronic or 39 false positive anti-HCV reactive blood donors. The spontaneous recovery rate was 37.2%. Viral loads of 76 HCV plasmas ranged between 59.8IU/ml and 2.43×10 6IU/ml (median 3.67×10 4IU/ml). Genotypes 1, 2, 3 and 6 of 63 HCV strains were identified phylogenetically. Recovered donors were significantly younger (p=0.002) and had lower level IFN-γ (p=0.001) than chronically HCV infected donors. Circulating levels of IFN-α and IFN-γ were higher in those with low viral load and were low in middle or high viral load samples. The ratio of IFN-α to IFN-γ (IFN-α/γ) was significantly positively correlated with viral load (p=0.037), and viral load was inversely correlated with IFN-γ in chronic HCV infection regardless of genotype. The study revealed clearly different relationships between IFN-α and IFN-γ in relation to viral load in HCV. A novel measure of IFN-α/γ ratio could be a new approach to evaluate long term outcome of HCV infection. © 2011 Elsevier Inc. |
| spellingShingle | Li, T Chen, Z Zeng, J Zhang, J Wang, W Zhang, L Zheng, X Shuai, L Klenerman, P Allain, J Li, C Impact of host responses on control of hepatitis C virus infection in Chinese blood donors |
| title | Impact of host responses on control of hepatitis C virus infection in Chinese blood donors |
| title_full | Impact of host responses on control of hepatitis C virus infection in Chinese blood donors |
| title_fullStr | Impact of host responses on control of hepatitis C virus infection in Chinese blood donors |
| title_full_unstemmed | Impact of host responses on control of hepatitis C virus infection in Chinese blood donors |
| title_short | Impact of host responses on control of hepatitis C virus infection in Chinese blood donors |
| title_sort | impact of host responses on control of hepatitis c virus infection in chinese blood donors |
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