Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.

Twenty-three schizophrenic patients and 26 age-matched control subjects were studied using the P300 recorded during the auditory oddball task, with counting. Our aim was to assess the most suitable method of measurement and analysis of P300 amplitude and latency for use in clinical studies of schizo...

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Main Authors: Glabus, M, Blackwood, D, Ebmeier, K, Souza, V, Walker, M, Sharp, C, Dunan, J, Muir, W
Format: Journal article
Language:English
Published: 1994
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author Glabus, M
Blackwood, D
Ebmeier, K
Souza, V
Walker, M
Sharp, C
Dunan, J
Muir, W
author_facet Glabus, M
Blackwood, D
Ebmeier, K
Souza, V
Walker, M
Sharp, C
Dunan, J
Muir, W
author_sort Glabus, M
collection OXFORD
description Twenty-three schizophrenic patients and 26 age-matched control subjects were studied using the P300 recorded during the auditory oddball task, with counting. Our aim was to assess the most suitable method of measurement and analysis of P300 amplitude and latency for use in clinical studies of schizophrenia. The effect of high-pass filtering, peak definition method and recording electrode site were all investigated. We have developed a technique, based on a least-mean-squares approximation to data, which seems particularly well suited to dealing with multi-peak P300 complexes. We have also investigated the spectral composition of the P300 and have found some evidence to support a proposed 2-frequency model of the P300 complex.
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spelling oxford-uuid:842df3ca-dc03-469f-aad6-db075775f2902022-03-26T21:49:28ZMethodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:842df3ca-dc03-469f-aad6-db075775f290EnglishSymplectic Elements at Oxford1994Glabus, MBlackwood, DEbmeier, KSouza, VWalker, MSharp, CDunan, JMuir, WTwenty-three schizophrenic patients and 26 age-matched control subjects were studied using the P300 recorded during the auditory oddball task, with counting. Our aim was to assess the most suitable method of measurement and analysis of P300 amplitude and latency for use in clinical studies of schizophrenia. The effect of high-pass filtering, peak definition method and recording electrode site were all investigated. We have developed a technique, based on a least-mean-squares approximation to data, which seems particularly well suited to dealing with multi-peak P300 complexes. We have also investigated the spectral composition of the P300 and have found some evidence to support a proposed 2-frequency model of the P300 complex.
spellingShingle Glabus, M
Blackwood, D
Ebmeier, K
Souza, V
Walker, M
Sharp, C
Dunan, J
Muir, W
Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.
title Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.
title_full Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.
title_fullStr Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.
title_full_unstemmed Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.
title_short Methodological considerations in measurement of the P300 component of the auditory oddball ERP in schizophrenia.
title_sort methodological considerations in measurement of the p300 component of the auditory oddball erp in schizophrenia
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