The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.

DNA double-strand breaks (DSBs) can cause chromosomal rearrangements and extensive loss of heterozygosity (LOH), hallmarks of cancer cells. Yet, how such events are normally suppressed is unclear. Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous recombination (...

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Bibliographic Details
Main Authors:	Blaikley, E, Tinline-Purvis, H, Kasparek, T, Marguerat, S, Sarkar, S, Hulme, L, Hussey, S, Wee, B, Deegan, R, Walker, C, Pai, C, Bähler, J, Nakagawa, T, Humphrey, T
Format:	Journal article
Language:	English
Published:	Oxford University Press 2014

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.

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