Rapid stereoselective syntheses of heteroarene-fused azacycles via diastereoselective conjugate addition of heteroaryl substituted lithium amides
Conjugate addition of heteroaryl substituted lithium amides to a range of α,β-unsaturated esters followed by in situ enolate oxidation with (–)-(camphorsulfonyl)oxaziridine gave the corresponding α-hydroxy-β-amino esters. Subsequent Friedel-Crafts type cyclisation of these α-hydroxy-β-amino esters g...
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Bibliographic Details
| Main Authors: |
Davies, S,
Fletcher, A,
Holder, K,
Roberts, P,
Thomson, J,
Zimmer, D |
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| Format: | Journal article
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| Published: |
Japan Institute of Heterocyclic Chemistry
2018
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