11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rode...

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Bibliographic Details
Main Authors:	Morgan, SA, Sherlock, M, Gathercole, L, Lavery, G, Lenaghan, C, Bujalska, I, Laber, D, Yu, A, Convey, G, Mayers, R, Hegyi, K, Sethi, J, Stewart, P, Smith, D, Tomlinson, J
Format:	Journal article
Language:	English
Published:	2009

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