The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans.
The nematode, Caenorhabditis elegans, possesses the most extensive known superfamily of cys-loop ligand-gated ion channels (cys-loop LGICs) consisting of 102 subunit-encoding genes. Less than half of these genes have been functionally characterised which include cation-permeable channels gated by ac...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826282517528838144 |
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| author | Jones, A Sattelle, D |
| author_facet | Jones, A Sattelle, D |
| author_sort | Jones, A |
| collection | OXFORD |
| description | The nematode, Caenorhabditis elegans, possesses the most extensive known superfamily of cys-loop ligand-gated ion channels (cys-loop LGICs) consisting of 102 subunit-encoding genes. Less than half of these genes have been functionally characterised which include cation-permeable channels gated by acetylcholine (ACh) and gamma-aminobutyric acid (GABA) as well as anion-selective channels gated by ACh, GABA, glutamate and serotonin. Following the guidelines set for genetic nomenclature for C. elegans, we have designated unnamed subunits as lgc genes (ligand-gated ion channels of the cys-loop superfamily). Phylogenetic analysis shows that several of these lgc subunits form distinct groups which may represent novel cys-loop LGIC subtypes. |
| first_indexed | 2024-03-07T00:45:03Z |
| format | Journal article |
| id | oxford-uuid:8456dafd-a5b5-422c-a418-1b6cbab4fae0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:45:03Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:8456dafd-a5b5-422c-a418-1b6cbab4fae02022-03-26T21:50:32ZThe cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8456dafd-a5b5-422c-a418-1b6cbab4fae0EnglishSymplectic Elements at Oxford2008Jones, ASattelle, DThe nematode, Caenorhabditis elegans, possesses the most extensive known superfamily of cys-loop ligand-gated ion channels (cys-loop LGICs) consisting of 102 subunit-encoding genes. Less than half of these genes have been functionally characterised which include cation-permeable channels gated by acetylcholine (ACh) and gamma-aminobutyric acid (GABA) as well as anion-selective channels gated by ACh, GABA, glutamate and serotonin. Following the guidelines set for genetic nomenclature for C. elegans, we have designated unnamed subunits as lgc genes (ligand-gated ion channels of the cys-loop superfamily). Phylogenetic analysis shows that several of these lgc subunits form distinct groups which may represent novel cys-loop LGIC subtypes. |
| spellingShingle | Jones, A Sattelle, D The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. |
| title | The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. |
| title_full | The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. |
| title_fullStr | The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. |
| title_full_unstemmed | The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. |
| title_short | The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans. |
| title_sort | cys loop ligand gated ion channel gene superfamily of the nematode caenorhabditis elegans |
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