CoV-AbDab: the coronavirus antibody database
<p><strong>Motivation</strong> The emergence of a novel strain of betacoronavirus, SARS-CoV-2, has led to a pandemic that has been associated with over 700 000 deaths as of August 5, 2020. Research is ongoing around the world to create vaccines and therapies to minimize rates of di...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2020
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| _version_ | 1797079414785179648 |
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| author | Raybould, MIJ Kovaltsuk, A Marks, C Deane, C |
| author_facet | Raybould, MIJ Kovaltsuk, A Marks, C Deane, C |
| author_sort | Raybould, MIJ |
| collection | OXFORD |
| description | <p><strong>Motivation</strong>
The emergence of a novel strain of betacoronavirus, SARS-CoV-2, has led to a pandemic that has been associated with over 700 000 deaths as of August 5, 2020. Research is ongoing around the world to create vaccines and therapies to minimize rates of disease spread and mortality. Crucial to these efforts are molecular characterizations of neutralizing antibodies to SARS-CoV-2. Such antibodies would be valuable for measuring vaccine efficacy, diagnosing exposure and developing effective biotherapeutics. Here, we describe our new database, CoV-AbDab, which already contains data on over 1400 published/patented antibodies and nanobodies known to bind to at least one betacoronavirus. This database is the first consolidation of antibodies known to bind SARS-CoV-2 as well as other betacoronaviruses such as SARS-CoV-1 and MERS-CoV. It contains relevant metadata including evidence of cross-neutralization, antibody/nanobody origin, full variable domain sequence (where available) and germline assignments, epitope region, links to relevant PDB entries, homology models and source literature.</p>
<p><strong>Results</strong>
On August 5, 2020, CoV-AbDab referenced sequence information on 1402 anti-coronavirus antibodies and nanobodies, spanning 66 papers and 21 patents. Of these, 1131 bind to SARS-CoV-2.</p>
<p><strong>Availability and implementation</strong>
CoV-AbDab is free to access and download without registration at http://opig.stats.ox.ac.uk/webapps/coronavirus. Community submissions are encouraged.</p> |
| first_indexed | 2024-03-07T00:45:29Z |
| format | Journal article |
| id | oxford-uuid:847edf55-57c1-4df0-a1dd-345094103e34 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:45:29Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:847edf55-57c1-4df0-a1dd-345094103e342022-03-26T21:51:30ZCoV-AbDab: the coronavirus antibody databaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:847edf55-57c1-4df0-a1dd-345094103e34EnglishSymplectic ElementsOxford University Press2020Raybould, MIJKovaltsuk, AMarks, CDeane, C<p><strong>Motivation</strong> The emergence of a novel strain of betacoronavirus, SARS-CoV-2, has led to a pandemic that has been associated with over 700 000 deaths as of August 5, 2020. Research is ongoing around the world to create vaccines and therapies to minimize rates of disease spread and mortality. Crucial to these efforts are molecular characterizations of neutralizing antibodies to SARS-CoV-2. Such antibodies would be valuable for measuring vaccine efficacy, diagnosing exposure and developing effective biotherapeutics. Here, we describe our new database, CoV-AbDab, which already contains data on over 1400 published/patented antibodies and nanobodies known to bind to at least one betacoronavirus. This database is the first consolidation of antibodies known to bind SARS-CoV-2 as well as other betacoronaviruses such as SARS-CoV-1 and MERS-CoV. It contains relevant metadata including evidence of cross-neutralization, antibody/nanobody origin, full variable domain sequence (where available) and germline assignments, epitope region, links to relevant PDB entries, homology models and source literature.</p> <p><strong>Results</strong> On August 5, 2020, CoV-AbDab referenced sequence information on 1402 anti-coronavirus antibodies and nanobodies, spanning 66 papers and 21 patents. Of these, 1131 bind to SARS-CoV-2.</p> <p><strong>Availability and implementation</strong> CoV-AbDab is free to access and download without registration at http://opig.stats.ox.ac.uk/webapps/coronavirus. Community submissions are encouraged.</p> |
| spellingShingle | Raybould, MIJ Kovaltsuk, A Marks, C Deane, C CoV-AbDab: the coronavirus antibody database |
| title | CoV-AbDab: the coronavirus antibody database |
| title_full | CoV-AbDab: the coronavirus antibody database |
| title_fullStr | CoV-AbDab: the coronavirus antibody database |
| title_full_unstemmed | CoV-AbDab: the coronavirus antibody database |
| title_short | CoV-AbDab: the coronavirus antibody database |
| title_sort | cov abdab the coronavirus antibody database |
| work_keys_str_mv | AT raybouldmij covabdabthecoronavirusantibodydatabase AT kovaltsuka covabdabthecoronavirusantibodydatabase AT marksc covabdabthecoronavirusantibodydatabase AT deanec covabdabthecoronavirusantibodydatabase |