Moving on out: transport and packaging of influenza viral RNA into virions
Influenza A viruses bear a segmented single stranded negative sense RNA genome that is replicated in the nucleus and the newly synthesized viral (v) RNA segments are exported from the nucleus and transported to the plasma membrane for packaging into progeny virions. Influenza viruses exploit many ho...
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| Format: | Journal article |
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Annual Reviews
2016
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| _version_ | 1797079437042253824 |
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| author | Fodor, E Lakdawala, S Subbarao, K |
| author_facet | Fodor, E Lakdawala, S Subbarao, K |
| author_sort | Fodor, E |
| collection | OXFORD |
| description | Influenza A viruses bear a segmented single stranded negative sense RNA genome that is replicated in the nucleus and the newly synthesized viral (v) RNA segments are exported from the nucleus and transported to the plasma membrane for packaging into progeny virions. Influenza viruses exploit many host proteins during these events and this is the portion of the viral life cycle when genetic reassortment among influenza viruses occurs, that allows influenza A viruses to expand their host range, virulence, and pandemic potential. We review recent studies on the export of vRNAs from the nucleus, their transport through the cytoplasm and packaging into progeny virus particles. Understanding these events and the constraints on genetic reassortment has implications for assessment of pandemic potential of newly emerged influenza viruses, vaccine production, viral fitness, and identification of novel therapeutic targets. |
| first_indexed | 2024-03-07T00:45:49Z |
| format | Journal article |
| id | oxford-uuid:849f489e-1893-4029-8ba2-3282561a8709 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:45:49Z |
| publishDate | 2016 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | oxford-uuid:849f489e-1893-4029-8ba2-3282561a87092022-03-26T21:52:13ZMoving on out: transport and packaging of influenza viral RNA into virionsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:849f489e-1893-4029-8ba2-3282561a8709Symplectic Elements at OxfordAnnual Reviews2016Fodor, ELakdawala, SSubbarao, KInfluenza A viruses bear a segmented single stranded negative sense RNA genome that is replicated in the nucleus and the newly synthesized viral (v) RNA segments are exported from the nucleus and transported to the plasma membrane for packaging into progeny virions. Influenza viruses exploit many host proteins during these events and this is the portion of the viral life cycle when genetic reassortment among influenza viruses occurs, that allows influenza A viruses to expand their host range, virulence, and pandemic potential. We review recent studies on the export of vRNAs from the nucleus, their transport through the cytoplasm and packaging into progeny virus particles. Understanding these events and the constraints on genetic reassortment has implications for assessment of pandemic potential of newly emerged influenza viruses, vaccine production, viral fitness, and identification of novel therapeutic targets. |
| spellingShingle | Fodor, E Lakdawala, S Subbarao, K Moving on out: transport and packaging of influenza viral RNA into virions |
| title | Moving on out: transport and packaging of influenza viral RNA into virions |
| title_full | Moving on out: transport and packaging of influenza viral RNA into virions |
| title_fullStr | Moving on out: transport and packaging of influenza viral RNA into virions |
| title_full_unstemmed | Moving on out: transport and packaging of influenza viral RNA into virions |
| title_short | Moving on out: transport and packaging of influenza viral RNA into virions |
| title_sort | moving on out transport and packaging of influenza viral rna into virions |
| work_keys_str_mv | AT fodore movingonouttransportandpackagingofinfluenzaviralrnaintovirions AT lakdawalas movingonouttransportandpackagingofinfluenzaviralrnaintovirions AT subbaraok movingonouttransportandpackagingofinfluenzaviralrnaintovirions |