Common variants in HNF-1 alpha and risk of type 2 diabetes.

Common variants in HNF-1 alpha and risk of type 2 diabetes.

AIMS/HYPOTHESIS: Mutations in the hepatocyte nuclear factor 1-alpha gene (HNF-1alpha, now known as the transcription factor 1 gene [TCF1]) cause the most common monogenic form of diabetes, MODY3, but it is not known if common variants in HNF-1a are associated with decreased transcriptional activity...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Holmkvist, J, Cervin, C, Lyssenko, V, Winckler, W, Anevski, D, Cilio, C, Almgren, P, Berglund, G, Nilsson, P, Tuomi, T, Lindgren, C, Altshuler, D, Groop, L
التنسيق:	Journal article
اللغة:	English
منشور في:	2006

مواد مشابهة

Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.
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Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
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Large-scale type 2 diabetes association analysis of low-frequency nonsynonymous coding variants in the HNF4A gene including up to 17,600 individuals
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Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.
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