Histone modifiers in cancer: friends or foes?
Covalent modifications of histones can regulate all DNA-dependent processes. In the last few years, it has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and th...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826282579803766784 |
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| author | Cohen, I Poręba, E Kamieniarz, K Schneider, R |
| author_facet | Cohen, I Poręba, E Kamieniarz, K Schneider, R |
| author_sort | Cohen, I |
| collection | OXFORD |
| description | Covalent modifications of histones can regulate all DNA-dependent processes. In the last few years, it has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machineries that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. This review discusses the biology and biochemistry of covalent histone posttranslational modifications (PTMs) and evaluates the dual role of their modifiers in cancer: as oncogenes that can initiate and amplify tumorigenesis or as tumor suppressors. |
| first_indexed | 2024-03-07T00:45:59Z |
| format | Journal article |
| id | oxford-uuid:84ad6aed-4b2e-4b02-941e-88a94d9b416f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:45:59Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:84ad6aed-4b2e-4b02-941e-88a94d9b416f2022-03-26T21:52:35ZHistone modifiers in cancer: friends or foes?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:84ad6aed-4b2e-4b02-941e-88a94d9b416fEnglishSymplectic Elements at Oxford2011Cohen, IPoręba, EKamieniarz, KSchneider, RCovalent modifications of histones can regulate all DNA-dependent processes. In the last few years, it has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machineries that set them are crucial regulators that can control cellular proliferation, differentiation, plasticity, and malignancy processes. This review discusses the biology and biochemistry of covalent histone posttranslational modifications (PTMs) and evaluates the dual role of their modifiers in cancer: as oncogenes that can initiate and amplify tumorigenesis or as tumor suppressors. |
| spellingShingle | Cohen, I Poręba, E Kamieniarz, K Schneider, R Histone modifiers in cancer: friends or foes? |
| title | Histone modifiers in cancer: friends or foes? |
| title_full | Histone modifiers in cancer: friends or foes? |
| title_fullStr | Histone modifiers in cancer: friends or foes? |
| title_full_unstemmed | Histone modifiers in cancer: friends or foes? |
| title_short | Histone modifiers in cancer: friends or foes? |
| title_sort | histone modifiers in cancer friends or foes |
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