Functional investigation of troponin with the homozygous HCM mutation, TNNT2 K280N, obtained from an explanted heart

Eitemau Tebyg

• The HCM-associated cardiac Troponin T mutation K280N causes reduced responsiveness to protein kinase A
  gan: Van Der Velden, J, et al.
  Cyhoeddwyd: (2012)
• The HCM-Associated Cardiac Troponin T Mutation K280N Increases the Energetic Cost of Tension Generation in Human Cardiac Myofibrils
  gan: Ferrara, C, et al.
  Cyhoeddwyd: (2013)
• The effect of HCM mutations in troponin T and troponin I on the calcium binding of human cardiac troponin
  gan: Redwood, C, et al.
  Cyhoeddwyd: (2001)
• Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy
  gan: Vasco Sequeira, et al.
  Cyhoeddwyd: (2022-09-01)
• Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation
  gan: Messer, A, et al.
  Cyhoeddwyd: (2016)