GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner

GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner

GTP cyclohydrolase (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin (BH4) biosynthesis. The catalysis of BH4 biosynthesis is tightly regulated for physiological neurotransmission, inflammation, and vascular tone. Paradoxically, BH4 has emerged as an oncometabolite regulating tumor growth,...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Wang, Z, Zhang, N, Zhang, M, Jiang, Y, Fischer, R, Ng, AS, Bridges, E, Zhang, W, Zeng, X, Luo, Q, Liang, J, Győrffy, B, Hublitz, P, Liang, Z, Kerr, D, Harris, AL, Cai, S
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: American Association for Cancer Research 2023

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