Conditional knockout of GCH1 in leukocytes and endothelial cells: A novel model to study tetrahydrobiopterin-dependent NOS functions in vivo

Conditional knockout of GCH1 in leukocytes and endothelial cells: A novel model to study tetrahydrobiopterin-dependent NOS functions in vivo

Xehetasun bibliografikoak
Egile Nagusiak:	McNeill, E, Chuaiphichai, S, Crabtree, M, Hale, A, Alp, N, Channon, K
Formatua:	Conference item
Argitaratua:	2012

Antzeko izenburuak

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
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A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
nork: Chuaiphichai, S, et al.
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201 Regulation of INOS Function, Redox State and NRF2 Activation by Macrophage GCH1 and Tetrahydrobiopterin.
nork: McNeill, E, et al.
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Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
nork: McNeill, E, et al.
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A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
nork: Douglas, G, et al.
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
nork: Chuaiphichai, S, et al.
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
nork: Chuaiphichai, S, et al.
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Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
nork: McNeill, E, et al.
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Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
nork: Eileen McNeill, et al.
Argitaratua: (2018-12-01)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
nork: Chuaiphichai, S, et al.
Argitaratua: (2014)

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
nork: Schmidt, T, et al.
Argitaratua: (2010)

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension
nork: Chuaiphichai, S, et al.
Argitaratua: (2015)

Low-dose Tetrahydrobiopterin Supplementation Reduces Atherosclerosis Progression in Apolipoprotein E-Knockout Mice via Effects on Vascular T cell Infiltration
nork: Schmidt, T, et al.
Argitaratua: (2009)

Long-term oral tetrahydrobiopterin supplementation reduces atherosclerosis in apolipoprotein e knockout mice
nork: Schmidt, T, et al.
Argitaratua: (2008)

Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
nork: Ali, Z, et al.
Argitaratua: (2007)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
nork: Ali, Z, et al.
Argitaratua: (2011)

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
nork: Benson, M, et al.
Argitaratua: (2013)

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.
nork: Chuaiphichai, S, et al.
Argitaratua: (2023)

Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
nork: Chuaiphichai, S, et al.
Argitaratua: (2021)

Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II
nork: Chuaiphichai, S, et al.
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The requirement for endothelial cell tetrahydrobiopterin in health and disease
nork: Chuaiphichai, S
Argitaratua: (2014)

Tetrahydrobiopterin in cardiovascular health and disease.
nork: Bendall, J, et al.
Argitaratua: (2014)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
nork: Ali, Z, et al.
Argitaratua: (2005)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
nork: Crabtree, M, et al.
Argitaratua: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
nork: Crabtree, M, et al.
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Endothelial cell tetrahydrobiopterin modulates sensitivity to Ang (Angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm
nork: Chuaiphichai, S, et al.
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Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
nork: Crabtree, M, et al.
Argitaratua: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
nork: Crabtree, M, et al.
Argitaratua: (2011)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
nork: Crabtree, M, et al.
Argitaratua: (2013)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
nork: Alp, N, et al.
Argitaratua: (2004)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
nork: Bendall, J, et al.
Argitaratua: (2005)

Tetrahydrobiopterin- and glutathionylation-dependent regulation of eNOS coupling: Relationships revealed by eNOS glutathionylation mutants in cells with tet-regulated GTP cyclohydrolase I expression
nork: Crabtree, M, et al.
Argitaratua: (2012)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
nork: Cai, S, et al.
Argitaratua: (2005)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
nork: Ali, Z, et al.
Argitaratua: (2006)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
nork: Adlam, D, et al.
Argitaratua: (2012)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
nork: Alp, N, et al.
Argitaratua: (2004)

The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
nork: McNeill, E, et al.
Argitaratua: (2012)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
nork: Adlam, D, et al.
Argitaratua: (2012)

Tetrahydrobiopterin-dependent eNOS coupling determines vascular remodeling through accelerated endothelial regeneration
nork: Ali, Z, et al.
Argitaratua: (2007)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
nork: Alp, N, et al.
Argitaratua: (2004)