Antibacterial drug releasing materials by post-polymerization surface modification
Functional materials are available by the post-polymerization surface modi¯cation of diverse polymers in a three-step process mediated, ¯rstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modi¯cation with a remotely tethered spiropyran unit, and these materials ma...
| Main Authors: | , , |
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| Format: | Journal article |
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World Scientific Publishing
2017
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| Summary: | Functional materials are available by the post-polymerization surface modi¯cation of diverse polymers in a three-step process mediated, ¯rstly, by carbene insertion chemistry, secondly, by diazonium coupling, and thirdly by modi¯cation with a remotely tethered spiropyran unit, and these materials may be used for the reversible binding and release of Penicillin V. Surface loading densities of up to 0.19 mmol/g polymer are achievable, leading to materials with higher loading densities and release behavior relative to unmodi¯ed controls, and observable antibacterial biocidal activity. |
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