Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

BACKGROUND: Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited thes...

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Huvudupphovsmän:	Jones, L, Holmans, P, Hamshere, M, Harold, D, Moskvina, V, Ivanov, D, Pocklington, A, Abraham, R, Hollingworth, P, Sims, R, Gerrish, A, Pahwa, J, Jones, N, Stretton, A, Morgan, A, Lovestone, S, Powell, J, Proitsi, P, Lupton, M, Brayne, C, Rubinsztein, D, Gill, M, Lawlor, B, Lynch, A, Morgan, K, Brown, K, Passmore, P, Craig, D, McGuinness, B, Todd, S, Holmes, C, Mann, D, Smith, D, Love, S, Kehoe, P, Mead, S, Fox, N, Rossor, M, Collinge, J, Maier, W, Jessen, F, Schürmann, B, Heun, R, Kölsch, H, van den Bussche, H, Heuser, I, Peters, O, Kornhuber, J, Wiltfang, J, Dichgans, M, Frölich, L, Hampel, H, Hüll, M, Rujescu, D, Goate, A, Kauwe, J, Cruchaga, C, Nowotny, P, Morris, J, Mayo, K, Livingston, G, Bass, N, Gurling, H, McQuillin, A, Gwilliam, R, Deloukas, P, Al-Chalabi, A, Shaw, C, Singleton, AB, Guerreiro, R, Mühleisen, T, Nöthen, M, Moebus, S, Jöckel, K, Klopp, N, Wichmann, H, Rüther, E, Carrasquillo, M, Pankratz, V, Younkin, S, Hardy, J, O'Donovan, M, Owen, M, Williams, J
Materialtyp:	Journal article
Språk:	English
Publicerad:	Public Library of Science 2010

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

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