Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium
Background We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity. Methods We harmonised data from seven prospective cohort studies of ol...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2021
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| _version_ | 1797079560347451392 |
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| author | Amadou, A Freisling, H Jenab, M Tsilidis, KK Trichopoulou, A Boffetta, P Van Guelpen, B Mokoroa, O Wilsgaard, T Kee, F Schöttker, B Ordóñez-Mena, JM Männistö, S Söderberg, S Vermeulen, RCH Quirós, JR Liao, LM Sinha, R Kuulasmaa, K Brenner, H Romieu, I |
| author_facet | Amadou, A Freisling, H Jenab, M Tsilidis, KK Trichopoulou, A Boffetta, P Van Guelpen, B Mokoroa, O Wilsgaard, T Kee, F Schöttker, B Ordóñez-Mena, JM Männistö, S Söderberg, S Vermeulen, RCH Quirós, JR Liao, LM Sinha, R Kuulasmaa, K Brenner, H Romieu, I |
| author_sort | Amadou, A |
| collection | OXFORD |
| description | Background
We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity.
Methods
We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis.
Results
A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity.
Conclusions
Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans.
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| first_indexed | 2024-03-07T00:47:41Z |
| format | Journal article |
| id | oxford-uuid:85426259-76ba-4a69-b8d2-4c310484052f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:47:41Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:85426259-76ba-4a69-b8d2-4c310484052f2022-03-26T21:56:19ZPrevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortiumJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:85426259-76ba-4a69-b8d2-4c310484052fEnglishSymplectic ElementsSpringer Nature2021Amadou, AFreisling, HJenab, MTsilidis, KKTrichopoulou, ABoffetta, PVan Guelpen, BMokoroa, OWilsgaard, TKee, FSchöttker, BOrdóñez-Mena, JMMännistö, SSöderberg, SVermeulen, RCHQuirós, JRLiao, LMSinha, RKuulasmaa, KBrenner, HRomieu, IBackground We investigated whether associations between prevalent diabetes and cancer risk are pertinent to older adults and whether associations differ across subgroups of age, body weight status or levels of physical activity. Methods We harmonised data from seven prospective cohort studies of older individuals in Europe and the United States participating in the CHANCES consortium. Cox proportional hazard regression was used to estimate the associations of prevalent diabetes with cancer risk (all cancers combined, and for colorectum, prostate and breast). We calculated summary risk estimates across cohorts using pooled analysis and random-effects meta-analysis. Results A total of 667,916 individuals were included with an overall median (P25–P75) age at recruitment of 62.3 (57–67) years. During a median follow-up time of 10.5 years, 114,404 total cancer cases were ascertained. Diabetes was not associated with the risk of all cancers combined (hazard ratio (HR) = 0.94; 95% confidence interval (CI): 0.86–1.04; I2 = 63.3%). Diabetes was positively associated with colorectal cancer risk in men (HR = 1.17; 95% CI: 1.08–1.26; I2 = 0%) and a similar HR in women (1.13; 95% CI: 0.82–1.56; I2 = 46%), but with a confidence interval including the null. Diabetes was inversely associated with prostate cancer risk (HR = 0.81; 95% CI: 0.77–0.85; I2 = 0%), but not with postmenopausal breast cancer (HR = 0.96; 95% CI: 0.89–1.03; I2 = 0%). In exploratory subgroup analyses, diabetes was inversely associated with prostate cancer risk only in men with overweight or obesity. Conclusions Prevalent diabetes was positively associated with colorectal cancer risk and inversely associated with prostate cancer risk in older Europeans and Americans. |
| spellingShingle | Amadou, A Freisling, H Jenab, M Tsilidis, KK Trichopoulou, A Boffetta, P Van Guelpen, B Mokoroa, O Wilsgaard, T Kee, F Schöttker, B Ordóñez-Mena, JM Männistö, S Söderberg, S Vermeulen, RCH Quirós, JR Liao, LM Sinha, R Kuulasmaa, K Brenner, H Romieu, I Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium |
| title | Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium |
| title_full | Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium |
| title_fullStr | Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium |
| title_full_unstemmed | Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium |
| title_short | Prevalent diabetes and risk of total, colorectal, prostate and breast cancers in an ageing population: meta-analysis of individual participant data from cohorts of the CHANCES consortium |
| title_sort | prevalent diabetes and risk of total colorectal prostate and breast cancers in an ageing population meta analysis of individual participant data from cohorts of the chances consortium |
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