The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice.
The technique of in vivo depletion with T cell subset-specific monoclonal antibodies was used to study the involvement of CD8+T cells in protection/pathogenesis during the acute and chronic demyelinating phases of Theiler's murine encephalomyelitis virus (TMEV)-induced disease. Mice rendered CD...
| 主要な著者: | , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
1992
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| _version_ | 1826282696536489984 |
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| author | Borrow, P Tonks, P Welsh, C Nash, A |
| author_facet | Borrow, P Tonks, P Welsh, C Nash, A |
| author_sort | Borrow, P |
| collection | OXFORD |
| description | The technique of in vivo depletion with T cell subset-specific monoclonal antibodies was used to study the involvement of CD8+T cells in protection/pathogenesis during the acute and chronic demyelinating phases of Theiler's murine encephalomyelitis virus (TMEV)-induced disease. Mice rendered CD8-deficient prior to infection with TMEV were less efficient at clearing virus from the central nervous system compared to intact animals and also suffered demyelinating disease of earlier onset and increased severity. This indicates that CD8+ cells have a protective role in virus clearance at early times post-infection, and may also be involved in downregulating the severity of the chronic demyelinating disease. How CD8+ T cells function to produce these effects is discussed. |
| first_indexed | 2024-03-07T00:47:45Z |
| format | Journal article |
| id | oxford-uuid:854650d7-0f3e-4522-8bd2-bae5ca8503b6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:47:45Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:854650d7-0f3e-4522-8bd2-bae5ca8503b62022-03-26T21:56:23ZThe role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:854650d7-0f3e-4522-8bd2-bae5ca8503b6EnglishSymplectic Elements at Oxford1992Borrow, PTonks, PWelsh, CNash, AThe technique of in vivo depletion with T cell subset-specific monoclonal antibodies was used to study the involvement of CD8+T cells in protection/pathogenesis during the acute and chronic demyelinating phases of Theiler's murine encephalomyelitis virus (TMEV)-induced disease. Mice rendered CD8-deficient prior to infection with TMEV were less efficient at clearing virus from the central nervous system compared to intact animals and also suffered demyelinating disease of earlier onset and increased severity. This indicates that CD8+ cells have a protective role in virus clearance at early times post-infection, and may also be involved in downregulating the severity of the chronic demyelinating disease. How CD8+ T cells function to produce these effects is discussed. |
| spellingShingle | Borrow, P Tonks, P Welsh, C Nash, A The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. |
| title | The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. |
| title_full | The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. |
| title_fullStr | The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. |
| title_full_unstemmed | The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. |
| title_short | The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. |
| title_sort | role of cd8 t cells in the acute and chronic phases of theiler s murine encephalomyelitis virus induced disease in mice |
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