The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.

The BACE gene: genomic structure and candidate gene study in late-onset Alzheimer's disease.

Alzheimer's disease (AD) pathology is characterized by beta-amyloid plaques and neurofibrillary tangles. Studies of autosomal dominant early-onset AD mutations suggest that beta-amyloid overproduction is sufficient to cause AD. Recently, the BACE gene, which encodes beta-secretase, the rate lim...

Full description

Bibliographic Details
Main Authors:	Murphy, T, Yip, A, Brayne, C, Easton, D, Evans, J, Xuereb, J, Cairns, N, Esiri, M, Rubinsztein, D
Format:	Journal article
Language:	English
Published:	2001

Similar Items

Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease.
by: Taylor, A, et al.
Published: (2001)

The ACE gene and Alzheimer's disease susceptibility.
by: Narain, Y, et al.
Published: (2000)

Presenilin-1 intron 8 polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease.
by: Tysoe, C, et al.
Published: (1997)

HLA class I, II and III genes in confirmed late-onset Alzheimer's disease.
by: Lehmann, D, et al.
Published: (2001)

A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease.
by: Tysoe, C, et al.
Published: (1998)

LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD).
by: Sarah Lincoln, et al.
Published: (2013-01-01)

Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK.
by: Dow, D, et al.
Published: (1999)

KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers.
by: Deborah G Murdock, et al.
Published: (2013-01-01)

Identification of candidate genes associated with clinical onset of Alzheimer’s disease
by: Wang Liao, et al.
Published: (2022-12-01)

<it>BACE1 </it>gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease
by: Minthon Lennart, et al.
Published: (2010-09-01)

Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
by: Esiri, M, et al.
Published: (2001)

Identification of a BACE1 Binding Peptide Candidate for the Prevention of Amyloid Beta in Alzheimer’s Disease
by: Justin Read, et al.
Published: (2019-08-01)

Relationship between Adiponectin Gene Polymorphisms and Late-Onset Alzheimer's Disease.
by: Wei Li, et al.
Published: (2015-01-01)

Characterization of the canine <it>CLCN3 </it>gene and evaluation as candidate for late-onset NCL
by: Distl Ottmar, et al.
Published: (2006-03-01)

Role of BACE1 in Alzheimer’s synaptic function
by: Brati Das, et al.
Published: (2017-08-01)

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment
by: Judite R. M. Coimbra, et al.
Published: (2018-05-01)

Evaluation of Utilizing the Distinct Genes as Predictive Biomarkers in Late-Onset Alzheimer's Disease
by: Sercan Kenanoglu, et al.
Published: (2022-06-01)

Investigation of base excision repair gene variants in late-onset Alzheimer's disease.
by: Tugce Ertuzun, et al.
Published: (2019-01-01)

Molecular dynamics simulations of Alzheimer's BACE1 and BACE2 transmembrane domains in neurons: Impact of cholesterol
by: Juan Carlos Cruz-Jiménez, et al.
Published: (2021-03-01)

The Alzheimer's disease β-secretase enzyme, BACE1
by: Vassar Robert, et al.
Published: (2007-11-01)

Identification of gene networks mediating regional resistance to tauopathy in late-onset Alzheimer's disease.
by: Christopher A Ayoub, et al.
Published: (2023-03-01)

The C677T polymorphism of the methylenetetrahydrofolate reductase gene and susceptibility to late-onset Alzheimer’s disease
by: Yi Jian, et al.
Published: (2019-01-01)

Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.
by: Julio Barrera, et al.
Published: (2018-01-01)

BACE1, the Alzheimer's beta-secretase enzyme, in health and disease
by: Vassar Robert
Published: (2012-02-01)

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease
by: Miguel A. Maia, et al.
Published: (2019-03-01)

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease
by: Maria V. Fernández, et al.
Published: (2018-04-01)

Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
by: Merok Marianne A, et al.
Published: (2010-05-01)

The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease
by: Ulf Neumann, et al.
Published: (2018-09-01)

TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype.
by: Davidson, Y, et al.
Published: (2011)

Epistatic genetic effects among Alzheimer's candidate genes.
by: Timothy J Hohman, et al.
Published: (2013-01-01)

Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk
by: Juraj Javor, et al.
Published: (2024-03-01)

Gene expression of serotonergic markers in peripheral blood mononuclear cells of patients with late-onset Alzheimer's disease
by: Masoud Neshan, et al.
Published: (2020-08-01)

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
by: Ravi S. Pandey, et al.
Published: (2019-12-01)

BACE1 Inhibitors for Alzheimer’s Disease: The Past, Present and Any Future?
by: Firas H. Bazzari, et al.
Published: (2022-12-01)

Early‐onset Alzheimer's disease explained by polygenic risk of late‐onset disease?
by: William G. Mantyh, et al.
Published: (2023-10-01)

Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer’s disease
by: Nobendu Mukerjee, et al.
Published: (2022-08-01)

HERPESVIRUS INFECTIONS AND CLINICAL-IMMUNOLOGIC INTERACTIONS IN PATIENTS WITH EARLY-ONSET ALZHEIMER’S DISEASE AND LATE-ONSET ALZHEIMER’S DISEASE
by: I. K. Malashenkova, et al.
Published: (2021-10-01)

Language Changes in Late-Onset Alzheimer’s Disease
by: Eda Can, et al.
Published: (2019-04-01)

Multitarget Approach to Drug Candidates against Alzheimer’s Disease Related to AChE, SERT, BACE1 and GSK3β Protein Targets
by: Larisa Ivanova, et al.
Published: (2020-04-01)

Hyaluronan Synthase 1: A Novel Candidate Gene Associated With Late-Onset Non-syndromic Hereditary Hearing Loss
by: Alphonse Umugire, et al.
Published: (2022-08-01)