Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb.
FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transge...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826282751152619520 |
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| author | Brownlie, R Lawlor, K Niederer, H Cutler, A Xiang, Z Clatworthy, MR Floto, R Greaves, D Lyons, P Smith, K |
| author_facet | Brownlie, R Lawlor, K Niederer, H Cutler, A Xiang, Z Clatworthy, MR Floto, R Greaves, D Lyons, P Smith, K |
| author_sort | Brownlie, R |
| collection | OXFORD |
| description | FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease. |
| first_indexed | 2024-03-07T00:48:34Z |
| format | Journal article |
| id | oxford-uuid:858f89b1-345a-4d03-a5e2-50a41e3f070f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:48:34Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:858f89b1-345a-4d03-a5e2-50a41e3f070f2022-03-26T21:58:20ZDistinct cell-specific control of autoimmunity and infection by FcgammaRIIb.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:858f89b1-345a-4d03-a5e2-50a41e3f070fEnglishSymplectic Elements at Oxford2008Brownlie, RLawlor, KNiederer, HCutler, AXiang, ZClatworthy, MRFloto, RGreaves, DLyons, PSmith, KFcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease. |
| spellingShingle | Brownlie, R Lawlor, K Niederer, H Cutler, A Xiang, Z Clatworthy, MR Floto, R Greaves, D Lyons, P Smith, K Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. |
| title | Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. |
| title_full | Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. |
| title_fullStr | Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. |
| title_full_unstemmed | Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. |
| title_short | Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb. |
| title_sort | distinct cell specific control of autoimmunity and infection by fcgammariib |
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