Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid

Proliferation and invasion of cancer cells require favorable pH, yet potentially toxic quantities of acid are produced metabolically. Membrane-bound transporters extrude acid from cancer cells, but little is known about the mechanisms that handle acid once it is released into the poorly-perfused ext...

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Main Authors: Hulikova, A, Black, N, Hsia, L, Wilding, J, Bodmer, W, Swietach, P
格式: Journal article
出版: National Academy of Sciences 2016