Can the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United Kingdom
<p><strong>Objective.</strong> To assess whether publication of national treatment guidelines improved the management of early RA in the UK.</p> <p><strong>Methods.</strong> Incident diagnoses of RA in persons aged over 18 years from 1995 to 2010 were ident...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2015
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| _version_ | 1826312156159672320 |
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| author | Judge, A Wallace, G Prieto-Alhambra, D Arden, NK Edwards, CJ |
| author_facet | Judge, A Wallace, G Prieto-Alhambra, D Arden, NK Edwards, CJ |
| author_sort | Judge, A |
| collection | OXFORD |
| description | <p><strong>Objective.</strong> To assess whether publication of national treatment guidelines improved the management of early RA in the UK.</p>
<p><strong>Methods.</strong> Incident diagnoses of RA in persons aged over 18 years from 1995 to 2010 were identified from the Clinical Practice Research Datalink. Using a natural experimental study design, interrupted time series analysis was used to assess whether trends in the proportion of patients receiving DMARDs, within 3 and 12 months of diagnosis, changed following publication of British Society for Rheumatology guidelines in 2006.</p>
<p><strong>Results.</strong> Between 1995 and 2010, 11 772 incident cases of RA were identified. There was a progressive increase in the proportion of patients prescribed any DMARD within 12 months from 43.3% in 1995 to 78.5% in 2010. After publication of the British Society for Rheumatology guidelines, the proportion of patients prescribed any DMARD within 12 months increased by 4.2% (P = 0.053). Prior to the guidance, prescribing was increasing by 1.64% per year, compared with 3.55% per year after publication (P < 0.001).</p>
<p><strong>Conclusion.</strong> Guidelines published by a national body can improve the proportion of patients receiving DMARD treatment in the first year after diagnosis of RA.</p> |
| first_indexed | 2024-03-07T08:23:21Z |
| format | Journal article |
| id | oxford-uuid:85b7de90-5e06-47c3-b1b5-85e0bffeb994 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:23:21Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:85b7de90-5e06-47c3-b1b5-85e0bffeb9942024-02-06T08:50:51ZCan the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United KingdomJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:85b7de90-5e06-47c3-b1b5-85e0bffeb994EnglishSymplectic Elements at OxfordOxford University Press2015Judge, AWallace, GPrieto-Alhambra, DArden, NKEdwards, CJ<p><strong>Objective.</strong> To assess whether publication of national treatment guidelines improved the management of early RA in the UK.</p> <p><strong>Methods.</strong> Incident diagnoses of RA in persons aged over 18 years from 1995 to 2010 were identified from the Clinical Practice Research Datalink. Using a natural experimental study design, interrupted time series analysis was used to assess whether trends in the proportion of patients receiving DMARDs, within 3 and 12 months of diagnosis, changed following publication of British Society for Rheumatology guidelines in 2006.</p> <p><strong>Results.</strong> Between 1995 and 2010, 11 772 incident cases of RA were identified. There was a progressive increase in the proportion of patients prescribed any DMARD within 12 months from 43.3% in 1995 to 78.5% in 2010. After publication of the British Society for Rheumatology guidelines, the proportion of patients prescribed any DMARD within 12 months increased by 4.2% (P = 0.053). Prior to the guidance, prescribing was increasing by 1.64% per year, compared with 3.55% per year after publication (P < 0.001).</p> <p><strong>Conclusion.</strong> Guidelines published by a national body can improve the proportion of patients receiving DMARD treatment in the first year after diagnosis of RA.</p> |
| spellingShingle | Judge, A Wallace, G Prieto-Alhambra, D Arden, NK Edwards, CJ Can the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United Kingdom |
| title | Can the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United Kingdom |
| title_full | Can the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United Kingdom |
| title_fullStr | Can the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United Kingdom |
| title_full_unstemmed | Can the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United Kingdom |
| title_short | Can the publication of guidelines change the management of early rheumatoid arthritis? An interrupted time series analysis from the United Kingdom |
| title_sort | can the publication of guidelines change the management of early rheumatoid arthritis an interrupted time series analysis from the united kingdom |
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