Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition.
p300 is a transcriptional cofactor and prototype histone acetyltransferase involved in regulating multiple cellular processes. We generated p300 deficient (p300-) cells from the colon carcinoma cell line HCT116 by gene targeting. Comparison of epithelial and mesenchymal proteins in p300- with parent...
| Main Authors: | , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2006
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