A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.

2-oxoglutarate (2-OG)-dependent oxygenases have diverse roles in human biology. The inhibition of several 2-OG oxygenases is being targeted for therapeutic intervention, including for cancer, anemia, and ischemic diseases. We report a small-molecule probe for 2-OG oxygenases that employs a hydroxyqu...

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Bibliographic Details
Main Authors:	Rotili, D, Altun, M, Kawamura, A, Wolf, A, Fischer, R, Leung, I, Mackeen, M, Tian, Y, Ratcliffe, P, Mai, A, Kessler, B, Schofield, C
Format:	Journal article
Language:	English
Published:	2011

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