Distinct roles for the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in human osteoclast formation and function

Distinct roles for the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in human osteoclast formation and function

Bone homeostasis is maintained by a balance between osteoblast-mediated bone formation and osteoclast-driven bone resorption. Hypoxia modulates this relationship partially via direct and indirect effects of the hypoxia-inducible factor-1 alpha (HIF-1α) transcription factor on osteoclast formation an...

תיאור מלא

מידע ביבליוגרפי
מחבר ראשי:	Knowles, H
פורמט:	Journal article
שפה:	English
יצא לאור:	Nature Research 2020

פריטים דומים

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
מאת: Sowter, H, et al.
יצא לאור: (2003)

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
מאת: Mole, D, et al.
יצא לאור: (2009)

Hypoxia, hypoxia-inducible factor (HIF) and bone homeostasis: focus on osteoclast-mediated bone resorption
מאת: Knowles, H
יצא לאור: (2015)

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
מאת: Talks, K, et al.
יצא לאור: (2000)

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
מאת: Freya M Mowat, et al.
יצא לאור: (2010-06-01)

The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2alpha but not HIF-1alpha.
מאת: Fox, S, et al.
יצא לאור: (2007)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
מאת: Elkins, J, et al.
יצא לאור: (2003)

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
מאת: Wiesener, MS, et al.
יצא לאור: (2003)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
מאת: Wood, S, et al.
יצא לאור: (1998)

Hypoxia inducible factor-1 alpha (Hif-1 alpha) polymorphism in lymphoma and reactive lymphoid hyperplasia
מאת: SEMA YILMAZ, et al.
יצא לאור: (2019-08-01)

Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.
מאת: Shaida, N, et al.
יצא לאור: (2008)

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
מאת: Elvidge, G, et al.
יצא לאור: (2006)

Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents.
מאת: Jessica Jie Wei Lou, et al.
יצא לאור: (2010-01-01)

Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.
מאת: Jennifer Adamski, et al.
יצא לאור: (2013-01-01)

Can HIF-1 Alpha (Hypoxia- inducible factor-1 alpha) be a New Cardiac Hypoxia Marker in Acute Coronary Ischemia?
מאת: Feray Akbaş, et al.
יצא לאור: (2021-06-01)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
מאת: Webb, J, et al.
יצא לאור: (2009)

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
מאת: Carmeliet, P, et al.
יצא לאור: (1998)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
מאת: Pollard, P, et al.
יצא לאור: (2008)

Tissue Expression of Hypoxia-Inducible Factor 1 Alpha (HIF-1A) in Wilms Tumor
מאת: Emel Tekin, et al.
יצא לאור: (2019-03-01)

Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study
מאת: Minas Marcos, et al.
יצא לאור: (2008-11-01)

The role of HIF-1 alpha in the localization of embryonic stem cells with respect to hypoxia within teratomas
מאת: Cochran, David M., Ph. D. Massachusetts Institute of Technology
יצא לאור: (2008)

An association study between hypoxia inducible factor-1alpha (HIF-1α) polymorphisms and osteonecrosis.
מאת: Georgia Chachami, et al.
יצא לאור: (2013-01-01)

Functional variation in the hypoxia-inducible factor (HIF) pathway in humans
מאת: Petousi, N
יצא לאור: (2012)

Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival.
מאת: Elisa Conde, et al.
יצא לאור: (2012-01-01)

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
מאת: Dahia, P, et al.
יצא לאור: (2005)

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
מאת: Patricia L M Dahia, et al.
יצא לאור: (2005-07-01)

A HIF1alpha Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas.
יצא לאור: (2005-07-01)

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism.
מאת: Cook, K, et al.
יצא לאור: (2009)

FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha.
מאת: Caroline Conte, et al.
יצא לאור: (2008-01-01)

Fih attenuates the hypoxic tolerance of Megalobrama amblycephala by inhibiting the activity of hypoxia-inducible factor alpha (hif-α)
מאת: Jun Li, et al.
יצא לאור: (2024-08-01)

Evaluation of Hypoxia-Inducible Factor-1 Alpha (HIF-1α) in Equine Sarcoid: An Immunohistochemical and Biochemical Study
מאת: Manuela Martano, et al.
יצא לאור: (2020-01-01)

Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility
מאת: S. E. Taylor, et al.
יצא לאור: (2016-01-01)

HIF-2alpha--a mediator of osteoarthritis?
מאת: Murphy, C
יצא לאור: (2010)

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia
מאת: Flora Cimmino, et al.
יצא לאור: (2019-02-01)

Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
מאת: Pollard, P, et al.
יצא לאור: (2006)

Effects of TLR agonists on the hypoxia-regulated transcription factor HIF-1alpha and dendritic cell maturation under normoxic conditions.
מאת: Rolf Spirig, et al.
יצא לאור: (2010-06-01)

The Hypoxia-Inducible Factor (HIF) pathway in adipocytes: The role of HIF-2 in adipose inflammation and hypertrophic cardiomyopathy
מאת: Zhong eYun, et al.
יצא לאור: (2015-03-01)

Hyperbaric Oxygen (HBO) Reduce Expression of Hypoxia Inducible Factor-1 Alpha (HIF-1 alpha) and Endometriotic Tissue Size in Mice Model of Endometriosis
מאת: Syahrizal Dedy, et al.
יצא לאור: (2020-01-01)

Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.
מאת: Biswas, S, et al.
יצא לאור: (2010)

miR-210 Protects Renal Cell Against Hypoxia-induced Apoptosis by Targeting HIF-1 Alpha
מאת: Li-Li Liu, et al.
יצא לאור: (2017-10-01)