Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo

Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo

Bibliografiska uppgifter
Huvudupphovsmän:	Roelofs, A, Boyde, A, Lundy, M, McKenna, C, Blazewska, K, Sun, S, Kashemirov, B, Russell, R, Ebetino, F, Rogers, M, Coxon, F
Materialtyp:	Conference item
Publicerad:	2009

Liknande verk

The Ability of Bisphosphonates and Their Analogues to Penetrate the Osteocyte Network is Dependent on Affinity for Bone
av: Roelofs, A, et al.
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Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo.
av: Roelofs, A, et al.
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Mineral binding affinities of bisphosphonates.
av: Nancollas, G, et al.
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A novel method to characterize relative mineral binding affinities of bisphosphonates and the structural requirements for binding by using ceramic hydroxyapatite column chromatography.
av: Xia, Z, et al.
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Mineral binding affinities and zeta potentials of bisphosphonates
av: Nancollas, G, et al.
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Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits.
av: Turek, J, et al.
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Comparative mineral binding affinities of selected bisphosphonates
av: Nancollas, G, et al.
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Refining structure activity relationships among nitrogen containing bisphosphonates: Dissociation of mineral binding affinity and inhibitory potency on farnesyl diphosphate synthase.
av: Xia, Z, et al.
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The Successful Design Of A Novel Highly Potent Nitrogen-Containing Bisphosphonate With Lower Bone Affinity.
av: Ebetino, F, et al.
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Bisphosphonate affinity to hydroxyapatite and farnesyl pyrophosphate inhibitory potency, together, drive in vivo efficacy
av: Lundy, M, et al.
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Predicting pharmacological potencies of nitrogen-containing bisphosphonates; novel methods dissociate enzyme- and hydroxyapatite-binding affinities
av: Xia, Z, et al.
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Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
av: Marma, MS, et al.
Publicerad: (2007)

Differences between bisphosphonates in binding affinities for hydroxyapatite.
av: Lawson, M, et al.
Publicerad: (2010)

Fluorescently labeled risedronate and related analogues: "magic linker" synthesis.
av: Kashemirov, B, et al.
Publicerad: (2008)

Evaluation of the relative mineral-binding affinities of clinically-relevant bisphosphonates by hydroxyapatite-column chromatography
av: Xia, Z, et al.
Publicerad: (2008)

A computational model explains bisphosphonate binding affinity differences on hydroxyapatite
av: Ebetino, F, et al.
Publicerad: (2006)

A computational model explains bisphosphonate binding affinity differences on hydroxyapatite
av: Ebetino, F, et al.
Publicerad: (2006)

Bisphosphonate binding affinity as assessed by inhibition of carbonated apatite dissolution in vitro.
av: Henneman, Z, et al.
Publicerad: (2008)

The relationship between the chemistry and biological activity of the bisphosphonates.
av: Ebetino, F, et al.
Publicerad: (2011)

Bisphosphonate bone affinity, differences predicted by in vitro binding to carbonated apatite
av: Henneman, Z, et al.
Publicerad: (2004)

Bisphosphonate bone affinity, differences predicted by in vitro carbonated apatite model.
av: Henneman, Z, et al.
Publicerad: (2003)

A computational model delineates differences in hydroxyapatite binding affinities of bisphosphonates in clinical use
av: Ebetino, E, et al.
Publicerad: (2005)

Refining the use of hydroxyapatite column chromatography to reveal differences in relative binding affinities of bisphosphonates
av: Lawson, M, et al.
Publicerad: (2006)

A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
av: Ebetino, F, et al.
Publicerad: (2008)

Predicting the clinical potencies of bisphosphonates: Divergence of hydroxyapatite and farnesyl diphosphate synthase binding affinities
av: Xia, Z, et al.
Publicerad: (2007)

Role of the geminal hydroxyl group in target enzyme inhibition by bisphosphonates and phosphonocarboxylates
av: Stewart, C, et al.
Publicerad: (2007)

Bisphosphonates: Mechanisms of Action
av: Roelofs, A, et al.
Publicerad: (2008)

BONE AFFINITY DIFFERENCES OF NITROGEN-CONTAINING BISPHOSPHONATES PREDICTED BY IN VITRO BINDING TO CARBONATED APATITE
av: Ebetino, F, et al.
Publicerad: (2004)

Determination of the relative bone mineral-binding affinities of bisphosphonates by using hydroxyapatite-column chromatography combined with mass spectrometric analysis
av: Duan, X, et al.
Publicerad: (2010)

Differential effects of alpha-halogenation on the potency of bisphosphonates and phosphonocarboxylates for inhibition of their target enzymes
av: Stewart, C, et al.
Publicerad: (2007)

The use of hydroxyapatite column chromatography as a novel method to reveal differences in relative binding affinities of bisphosphonates
av: Lawson, M, et al.
Publicerad: (2005)

Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase
av: Ebetino, F, et al.
Publicerad: (2006)

Evaluation of the relative mineral-binding affinities of clinically-relevant bisphosphonates by using hydroxyapatite-column chromatography and adsorption isotherms combined with mass spectrometric analysis
av: Xia, Z, et al.
Publicerad: (2008)

Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities
av: Xia, Z, et al.
Publicerad: (2007)

Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes
av: Coxon, F, et al.
Publicerad: (2008)

Fluorescently labeled risedronate and related analocs: Design and evaluation as imaging probes
av: Coxon, F, et al.
Publicerad: (2008)

MEDI 73-Modeling, synthetic, crystallographic, and activity studies of novel bisphosphonates as inhibitors of farnesyl pyrophosphate synthase
av: Hogan, J, et al.
Publicerad: (2007)

A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation
av: Abigail A Coffman, et al.
Publicerad: (2021-04-01)

Synthesis of novel bisphosphonate polyamine conjugates and their affinity to hydroxyapatite
av: Elina Sankala, et al.
Publicerad: (2012-02-01)

Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation
av: Abigail A Coffman, et al.
Publicerad: (2021-07-01)