Loss Of COP9-signalosome genes Aa 2q37 is associated with IMiD agent resistance in multiple myeloma

Loss Of COP9-signalosome genes Aa 2q37 is associated with IMiD agent resistance in multiple myeloma

The acquisition of a multi-drug refractory state is a major cause of mortality in myeloma. Myeloma drugs that target the Cereblon (CRBN) protein include widely-used immunomodulatory drugs (IMiDs), and newer CRBN E3 ligase modulator drugs (CELMoDs), in clinical trials. CRBN genetic disruption causes...

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Bibliographic Details
Main Authors:	Gooding, S, Ansari-Pour, N, Kazeroun, MH, Karagoz, K, Polonskaia, A, Angulo Salazar, M, Fitzsimons, E, Sirinukunwattana, K, Chavda, SJ, Ortiz Estevez, M, Towfic, F, Flynt, E, Pierceall, W, Royston, D, Yong, KL, Ramasamy, K, Vyas, P, Thakurta, A
Format:	Journal article
Language:	English
Published:	American Society of Hematology 2022

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