Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.

Activation of platelets by collagen is mediated by the complex glycoprotein VI (GPVI)/Fc receptor gamma (FcR gamma chain). In the current study, the role of 2 Src family kinases, Fyn and Lyn, in GPVI signaling has been examined using murine platelets deficient in one or both kinases. In the fyn(-/-)...

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Detalles Bibliográficos
Main Authors: Quek, L, Pasquet, J, Hers, I, Cornall, R, Knight, G, Barnes, M, Hibbs, M, Dunn, A, Lowell, C, Watson, S
Formato: Journal article
Idioma:English
Publicado: 2000

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