Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam.
Acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolated between August 2010 and December 2014 from three large hospitals in Han...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer
2016
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| _version_ | 1826282863111176192 |
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| author | Tran, D Tran, H Matsui, M Suzuki, M Suzuki, S Shibayama, K Pham, T Van Phuong, T Dang, D Trinh, H Loan, C Nga, L van Doorn, H Wertheim, H |
| author_facet | Tran, D Tran, H Matsui, M Suzuki, M Suzuki, S Shibayama, K Pham, T Van Phuong, T Dang, D Trinh, H Loan, C Nga, L van Doorn, H Wertheim, H |
| author_sort | Tran, D |
| collection | OXFORD |
| description | Acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolated between August 2010 and December 2014 from three large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and seven from hospital C) that were NDM-1 positive, and among them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems. Genotyping indicated that NDM-1 carrying A. baumannii have expanded clonally in these hospitals. Five new STs (ST1135, ST1136, ST1137, ST1138, and ST1139) were identified. One isolate carried NDM-1 on a plasmid belonging to the N-repA replicon type; no NDM-1-positive plasmids were identified in the other isolates. We have shown the extent of the carbapenem resistance and the local clonal spread of A. baumannii carrying NDM-1 in these hospitals; coexistence of NDM-1 and IMP-1 is reported for the first time from Vietnam here, and this will further seriously limit future therapeutic options. |
| first_indexed | 2024-03-07T00:50:15Z |
| format | Journal article |
| id | oxford-uuid:86247118-1ad4-4119-b9c6-9e56a26bdd8c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:50:15Z |
| publishDate | 2016 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:86247118-1ad4-4119-b9c6-9e56a26bdd8c2022-03-26T22:02:07ZEmergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:86247118-1ad4-4119-b9c6-9e56a26bdd8cEnglishSymplectic Elements at OxfordSpringer2016Tran, DTran, HMatsui, MSuzuki, MSuzuki, SShibayama, KPham, TVan Phuong, TDang, DTrinh, HLoan, CNga, Lvan Doorn, HWertheim, HAcinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolated between August 2010 and December 2014 from three large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and seven from hospital C) that were NDM-1 positive, and among them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems. Genotyping indicated that NDM-1 carrying A. baumannii have expanded clonally in these hospitals. Five new STs (ST1135, ST1136, ST1137, ST1138, and ST1139) were identified. One isolate carried NDM-1 on a plasmid belonging to the N-repA replicon type; no NDM-1-positive plasmids were identified in the other isolates. We have shown the extent of the carbapenem resistance and the local clonal spread of A. baumannii carrying NDM-1 in these hospitals; coexistence of NDM-1 and IMP-1 is reported for the first time from Vietnam here, and this will further seriously limit future therapeutic options. |
| spellingShingle | Tran, D Tran, H Matsui, M Suzuki, M Suzuki, S Shibayama, K Pham, T Van Phuong, T Dang, D Trinh, H Loan, C Nga, L van Doorn, H Wertheim, H Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam. |
| title | Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam. |
| title_full | Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam. |
| title_fullStr | Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam. |
| title_full_unstemmed | Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam. |
| title_short | Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam. |
| title_sort | emergence of new delhi metallo beta lactamase 1 and other carbapenemase producing acinetobacter calcoaceticus baumannii complex among patients in hospitals in ha noi viet nam |
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