A THEMIS:SHP1 complex promotes T-cell survival.

A THEMIS:SHP1 complex promotes T-cell survival.

THEMIS is critical for conventional T-cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates with the phosphatases SHP1 and SHP2. This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr-phosphorylation-independen...

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Bibliografiska uppgifter
Huvudupphovsmän: Paster, W, Bruger, A, Katsch, K, Grégoire, C, Roncagalli, R, Fu, G, Gascoigne, N, Nika, K, Cohnen, A, Feller, S, Simister, P, Molder, K, Cordoba, S, Dushek, O, Malissen, B, Acuto, O
Materialtyp: Journal article
Språk:English
Publicerad: Wiley 2015

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