A THEMIS:SHP1 complex promotes T-cell survival.
THEMIS is critical for conventional T-cell development, but its precise molecular function remains elusive. Here, we show that THEMIS constitutively associates with the phosphatases SHP1 and SHP2. This complex requires the adapter GRB2, which bridges SHP to THEMIS in a Tyr-phosphorylation-independen...
Những tác giả chính: | Paster, W, Bruger, A, Katsch, K, Grégoire, C, Roncagalli, R, Fu, G, Gascoigne, N, Nika, K, Cohnen, A, Feller, S, Simister, P, Molder, K, Cordoba, S, Dushek, O, Malissen, B, Acuto, O |
---|---|
Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
Wiley
2015
|
Những quyển sách tương tự
-
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Bằng: Paster, W, et al.
Được phát hành: (2013) -
SHP1-ing thymic selection
Bằng: Gascoigne, N, et al.
Được phát hành: (2016) -
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.
Bằng: Brockmeyer, C, et al.
Được phát hành: (2011) -
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.
Bằng: Fu, G, et al.
Được phát hành: (2009) -
Determination of the molecular reach of the protein tyrosine phosphatase SHP-1
Bằng: Clemens, L, et al.
Được phát hành: (2021)