Polymer packaging and ejection in viral capsids: shape matters
We use a mesoscale simulation approach to explore the impact of different capsid geometries on the packagin and ejection dynamics of polymers of different flexibility. We find that both packing and ejection times are faster for flexible polymers. For such polymers a sphere packs more quickly and eje...
| 主要な著者: | , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
American Physical Society
2006
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| 主題: |
| _version_ | 1826282889276293120 |
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| author | Ali, I Marenduzzo, D Yeomans, J |
| author_facet | Ali, I Marenduzzo, D Yeomans, J |
| author_sort | Ali, I |
| collection | OXFORD |
| description | We use a mesoscale simulation approach to explore the impact of different capsid geometries on the packagin and ejection dynamics of polymers of different flexibility. We find that both packing and ejection times are faster for flexible polymers. For such polymers a sphere packs more quickly and ejects more slowly than an ellipsoid. For semiflexible polymers, however, the case relevant to DNA, a sphere both packs and ejects more easily. We interpret our results by considering both the thermodynamics and the relaxational dynamics of the polymers. The predictions could be tested with biomimetic experiments with synthetic polymers inside artificial vesicles. Our results suggest that phages may have evolved to be roughly spherical in shape to optimize the speed of genome ejection, which is the first stage in infection. |
| first_indexed | 2024-03-07T00:50:38Z |
| format | Journal article |
| id | oxford-uuid:8648b249-6d03-455f-9ae0-a8fd1e365c82 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:50:38Z |
| publishDate | 2006 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | oxford-uuid:8648b249-6d03-455f-9ae0-a8fd1e365c822022-03-26T22:02:57ZPolymer packaging and ejection in viral capsids: shape mattersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8648b249-6d03-455f-9ae0-a8fd1e365c82PhysicsTheoretical physicsEnglishOxford University Research Archive - ValetAmerican Physical Society2006Ali, IMarenduzzo, DYeomans, JWe use a mesoscale simulation approach to explore the impact of different capsid geometries on the packagin and ejection dynamics of polymers of different flexibility. We find that both packing and ejection times are faster for flexible polymers. For such polymers a sphere packs more quickly and ejects more slowly than an ellipsoid. For semiflexible polymers, however, the case relevant to DNA, a sphere both packs and ejects more easily. We interpret our results by considering both the thermodynamics and the relaxational dynamics of the polymers. The predictions could be tested with biomimetic experiments with synthetic polymers inside artificial vesicles. Our results suggest that phages may have evolved to be roughly spherical in shape to optimize the speed of genome ejection, which is the first stage in infection. |
| spellingShingle | Physics Theoretical physics Ali, I Marenduzzo, D Yeomans, J Polymer packaging and ejection in viral capsids: shape matters |
| title | Polymer packaging and ejection in viral capsids: shape matters |
| title_full | Polymer packaging and ejection in viral capsids: shape matters |
| title_fullStr | Polymer packaging and ejection in viral capsids: shape matters |
| title_full_unstemmed | Polymer packaging and ejection in viral capsids: shape matters |
| title_short | Polymer packaging and ejection in viral capsids: shape matters |
| title_sort | polymer packaging and ejection in viral capsids shape matters |
| topic | Physics Theoretical physics |
| work_keys_str_mv | AT alii polymerpackagingandejectioninviralcapsidsshapematters AT marenduzzod polymerpackagingandejectioninviralcapsidsshapematters AT yeomansj polymerpackagingandejectioninviralcapsidsshapematters |