Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation.
The tal-1 gene encodes a basic helix-loop-helix (bHLH) transcription factor required for primitive and definitive hematopoiesis. Additionally, ectopic activation of the tal-1 gene during T lymphopoiesis occurs in numerous cases of human T-cell acute lymphoblastic leukemia. With the use of transgenic...
Main Authors: | Goardon, N, Schuh, A, Hajar, I, Ma, X, Jouault, H, Dzierzak, E, Roméo, P, Maouche-Chrétien, L |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2002
|
Similar Items
-
Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
by: Julia Tornack, et al.
Published: (2013-01-01) -
Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos.
by: Ma, X, et al.
Published: (2002) -
RAG-1 and Ly6D independently reflect progression in the B lymphoid lineage.
by: Qingzhao Zhang, et al.
Published: (2013-01-01) -
Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates
by: Medya Mara Shikhagaie, et al.
Published: (2017-02-01) -
The role of Tal2 and Tal1 in the differentiation of midbrain GABAergic neuron precursors
by: Kaia Achim, et al.
Published: (2013-08-01)