IgG-mediated down-regulation of IgE bound to mast cells: A potential novel mechanism of allergen-specific desensitization

Background: Allergen-specific IgGs are known to inhibit IgE-mediated mast cell degranulation by two mechanisms, allergen-neutralization and engagement of the inhibitory FcγRIIB recruiting the phosphatase SHIP-1. Here we unravel an additional mechanism of IgG-mediated mast cell desensitization in mic...

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Những tác giả chính: Uermösi, C, Zabel, F, Manolova, V, Bauer, M, Beerli, R, Senti, G, Kündig, T, Saudan, P, Bachmann, M
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2014