GABA predicts time perception.
Our perception of time constrains our experience of the world and exerts a pivotal influence over a myriad array of cognitive and motor functions. There is emerging evidence that the perceived duration of subsecond intervals is driven by sensory-specific neural activity in human and nonhuman animals...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Society for Neuroscience
2014
|
| _version_ | 1797079843504914432 |
|---|---|
| author | Terhune, D Russo, S Near, J Stagg, C Cohen Kadosh, R |
| author_facet | Terhune, D Russo, S Near, J Stagg, C Cohen Kadosh, R |
| author_sort | Terhune, D |
| collection | OXFORD |
| description | Our perception of time constrains our experience of the world and exerts a pivotal influence over a myriad array of cognitive and motor functions. There is emerging evidence that the perceived duration of subsecond intervals is driven by sensory-specific neural activity in human and nonhuman animals, but the mechanisms underlying individual differences in time perception remain elusive. We tested the hypothesis that elevated visual cortex GABA impairs the coding of particular visual stimuli, resulting in a dampening of visual processing and concomitant positive time-order error (relative underestimation) in the perceived duration of subsecond visual intervals. Participants completed psychophysical tasks measuring visual interval discrimination and temporal reproduction and we measured in vivo resting state GABA in visual cortex using magnetic resonance spectroscopy. Time-order error selectively correlated with GABA concentrations in visual cortex, with elevated GABA associated with a rightward horizontal shift in psychometric functions, reflecting a positive time-order error (relative underestimation). These results demonstrate anatomical, neurochemical, and task specificity and suggest that visual cortex GABA contributes to individual differences in time perception. |
| first_indexed | 2024-03-07T00:51:36Z |
| format | Journal article |
| id | oxford-uuid:869751fa-8b95-4e38-bcb5-d09046998abe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:51:36Z |
| publishDate | 2014 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | oxford-uuid:869751fa-8b95-4e38-bcb5-d09046998abe2022-03-26T22:04:59ZGABA predicts time perception.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:869751fa-8b95-4e38-bcb5-d09046998abeEnglishSymplectic Elements at OxfordSociety for Neuroscience2014Terhune, DRusso, SNear, JStagg, CCohen Kadosh, ROur perception of time constrains our experience of the world and exerts a pivotal influence over a myriad array of cognitive and motor functions. There is emerging evidence that the perceived duration of subsecond intervals is driven by sensory-specific neural activity in human and nonhuman animals, but the mechanisms underlying individual differences in time perception remain elusive. We tested the hypothesis that elevated visual cortex GABA impairs the coding of particular visual stimuli, resulting in a dampening of visual processing and concomitant positive time-order error (relative underestimation) in the perceived duration of subsecond visual intervals. Participants completed psychophysical tasks measuring visual interval discrimination and temporal reproduction and we measured in vivo resting state GABA in visual cortex using magnetic resonance spectroscopy. Time-order error selectively correlated with GABA concentrations in visual cortex, with elevated GABA associated with a rightward horizontal shift in psychometric functions, reflecting a positive time-order error (relative underestimation). These results demonstrate anatomical, neurochemical, and task specificity and suggest that visual cortex GABA contributes to individual differences in time perception. |
| spellingShingle | Terhune, D Russo, S Near, J Stagg, C Cohen Kadosh, R GABA predicts time perception. |
| title | GABA predicts time perception. |
| title_full | GABA predicts time perception. |
| title_fullStr | GABA predicts time perception. |
| title_full_unstemmed | GABA predicts time perception. |
| title_short | GABA predicts time perception. |
| title_sort | gaba predicts time perception |
| work_keys_str_mv | AT terhuned gabapredictstimeperception AT russos gabapredictstimeperception AT nearj gabapredictstimeperception AT staggc gabapredictstimeperception AT cohenkadoshr gabapredictstimeperception |