Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome.
In the blood of 10 patients with rheumatoid arthritis (RA), the number of TCR gamma delta+T cells and CD5+B cells was 5.5% +/- 4.38 and 34.3% +/- 20.62 (mean +/- s.d.), respectively. In 12 patients with primary Sjögren's syndrome (SS) the mean +/- s.d. of these T and B cell subpopulations was 4...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1989
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| _version_ | 1797079858331779072 |
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| author | Brennan, F Plater-Zyberk, C Maini, R Feldmann, M |
| author_facet | Brennan, F Plater-Zyberk, C Maini, R Feldmann, M |
| author_sort | Brennan, F |
| collection | OXFORD |
| description | In the blood of 10 patients with rheumatoid arthritis (RA), the number of TCR gamma delta+T cells and CD5+B cells was 5.5% +/- 4.38 and 34.3% +/- 20.62 (mean +/- s.d.), respectively. In 12 patients with primary Sjögren's syndrome (SS) the mean +/- s.d. of these T and B cell subpopulations was 4.75% +/- 3.85 and 38.75% +/- 22.68. These values were significantly increased as compared with the circulating T and B cells from 22 healthy subjects in whom TCR gamma delta+T cells were 2.09 +/- 1.01 (P less than 0.001 for RA; P less than 0.004 for SS) and CD5+B cells were 18.09% +/- 4.47 (P less than 0.001 for RA and SS). This increase was not influenced by disease activity. Furthermore, there was a marked correlation (P less than 0.001) between the levels of TCR gamma delta +T cells and CD5+B cells. This novel finding of coordinate elevated levels of lymphocytes with fetal phenotypes in RA and primary SS suggests an immunological imbalance that may have implications in these diseases. |
| first_indexed | 2024-03-07T00:51:48Z |
| format | Journal article |
| id | oxford-uuid:86aabcc1-9a0a-4d28-b6ea-8e9160110bc6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:51:48Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:86aabcc1-9a0a-4d28-b6ea-8e9160110bc62022-03-26T22:05:27ZCoordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:86aabcc1-9a0a-4d28-b6ea-8e9160110bc6EnglishSymplectic Elements at Oxford1989Brennan, FPlater-Zyberk, CMaini, RFeldmann, MIn the blood of 10 patients with rheumatoid arthritis (RA), the number of TCR gamma delta+T cells and CD5+B cells was 5.5% +/- 4.38 and 34.3% +/- 20.62 (mean +/- s.d.), respectively. In 12 patients with primary Sjögren's syndrome (SS) the mean +/- s.d. of these T and B cell subpopulations was 4.75% +/- 3.85 and 38.75% +/- 22.68. These values were significantly increased as compared with the circulating T and B cells from 22 healthy subjects in whom TCR gamma delta+T cells were 2.09 +/- 1.01 (P less than 0.001 for RA; P less than 0.004 for SS) and CD5+B cells were 18.09% +/- 4.47 (P less than 0.001 for RA and SS). This increase was not influenced by disease activity. Furthermore, there was a marked correlation (P less than 0.001) between the levels of TCR gamma delta +T cells and CD5+B cells. This novel finding of coordinate elevated levels of lymphocytes with fetal phenotypes in RA and primary SS suggests an immunological imbalance that may have implications in these diseases. |
| spellingShingle | Brennan, F Plater-Zyberk, C Maini, R Feldmann, M Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome. |
| title | Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome. |
| title_full | Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome. |
| title_fullStr | Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome. |
| title_full_unstemmed | Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome. |
| title_short | Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjogren's syndrome. |
| title_sort | coordinate expansion of fetal type lymphocytes tcr gamma delta t and cd5 b in rheumatoid arthritis and primary sjogren s syndrome |
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