Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.

Fetal pancreatic beta cells demonstrate a deficient insulin release in response to glucose, but the underlying mechanism at the cellular level is unknown. By using beta cells from 21-day fetal rats we made an attempt to clarify the mechanism(s) behind this reduced glucose response. In addition to me...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Rorsman, P, Arkhammar, P, Bokvist, K, Hellerström, C, Nilsson, T, Welsh, M, Welsh, N, Berggren, P
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1989

Eitemau Tebyg

DEFECTIVE REGULATION OF GLUCOSE-REGULATED AND ATP-REGULATED K-CHANNELS RESULTS IN DISTURBED GLUCOSE SENSITIVITY IN FETAL B-CELLS
gan: Rorsman, P, et al.
Cyhoeddwyd: (1988)

GLUCOSE DOES NOT BLOCK ATP-REGULATED K+-CHANNEL ACTIVITY IN FETAL B-CELLS
gan: Welsh, M, et al.
Cyhoeddwyd: (1987)

Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic beta-cells.
gan: Arkhammar, P, et al.
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Glucose-induced increase in cytoplasmic pH in pancreatic beta-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.
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Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells.
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Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells.
gan: Smith, P, et al.
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Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP.
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CLONIDINE INHIBITION OF GLUCOSE-STIMULATED INSULIN-RELEASE INVOLVES REDUCTION OF THE CA-2+ CURRENT
gan: Rorsman, P, et al.
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Manganese accumulation in pancreatic beta-cells and its stimulation by glucose.
gan: Rorsman, P, et al.
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Mechanisms of action of entero-insular hormones and neural input on the insulin secretory process.
gan: Berggren, P, et al.
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ONTOGENY OF DIFFERENTIATION, GROWTH AND FUNCTION OF THE PANCREATIC B-CELL
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D-GLUCOSE AND D-GLYCERALDEHYDE HAVE OPPOSITE EFFECTS ON CYTOPLASMIC PH OF MOUSE PANCREATIC B-CELLS WHEN MEASURED BY THE FLUORESCENT PH-INDICATOR QUENE-1
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Inhibition of ATP-regulated K(+)-channels by a photoactivatable ATP-analogue in mouse pancreatic beta-cells.
gan: Ammälä, C, et al.
Cyhoeddwyd: (1991)

Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.
gan: Ammälä, C, et al.
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Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
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Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.
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CYTOPLASMIC PH OF MOUSE PANCREATIC BETA-CELLS AS MEASURED BY THE FLUORESCENT PH-INDICATOR QUENE-1
gan: Arkhammar, P, et al.
Cyhoeddwyd: (1986)

EVIDENCE THAT GLUCOSE-INDUCED DEPOLARIZATION IN THE PANCREATIC BETA-CELLS INVOLVES THE CLOSURE OF AN ATP-DEPENDENT K+-CHANNEL
gan: Rorsman, P, et al.
Cyhoeddwyd: (1985)

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.
gan: Bokvist, K, et al.
Cyhoeddwyd: (1991)

Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation.
gan: Kanno, T, et al.
Cyhoeddwyd: (2002)

Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the beta-cell?
gan: Ahrén, B, et al.
Cyhoeddwyd: (1989)

Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells.
gan: Ammälä, C, et al.
Cyhoeddwyd: (1993)

GLUCOSE-INDUCED RETENTION OF MANGANESE IN PANCREATIC BETA-CELLS
gan: Rorsman, P
Cyhoeddwyd: (1982)

Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells.
gan: Smith, P, et al.
Cyhoeddwyd: (1990)

Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine.
gan: Bokvist, K, et al.
Cyhoeddwyd: (1990)

Glucose-sensing mechanisms in pancreatic beta-cells.
gan: MacDonald, P, et al.
Cyhoeddwyd: (2005)

Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells.
gan: Rorsman, P
Cyhoeddwyd: (1982)

EVIDENCE THAT ADP AND ATP BIND AT DIFFERENT SITES AT THE G-CHANNEL
gan: Bokvist, K, et al.
Cyhoeddwyd: (1988)

ATP-REGULATED K+ CHANNELS AND DIABETES-MELLITUS
gan: Rorsman, P, et al.
Cyhoeddwyd: (1990)

Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.
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Cyhoeddwyd: (1980)

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
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Cyhoeddwyd: (2004)

Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells.
gan: Ammälä, C, et al.
Cyhoeddwyd: (1992)

Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.
gan: Eliasson, L, et al.
Cyhoeddwyd: (1996)

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
gan: Olsen, H, et al.
Cyhoeddwyd: (2003)

MANGANESE ACCUMULATION IN PANCREATIC B-CELLS DUE TO GLUCOSE INHIBITION OF OUTWARD TRANSPORT
gan: Rorsman, P, et al.
Cyhoeddwyd: (1981)

Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.
gan: Rorsman, P, et al.
Cyhoeddwyd: (1991)

Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells.
gan: Bokvist, K, et al.
Cyhoeddwyd: (1991)

Glucose in glucagon release.
gan: Rorsman, P, et al.
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ATP-dependence of exocytosis in mouse pancreatic beta-cells
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Cyhoeddwyd: (1997)

Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
gan: Arkhammar, P, et al.
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