Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation
Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson’s disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS). While beta fluctuations in PD patients are well characterized on shorter timescales, it is not known how beta...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2022
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| _version_ | 1797107289053724672 |
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| author | van Rheede, JJ Feldmann, LK Busch, JL Fleming, JE Mathiopoulou, V Denison, T Sharott, A Kühn, AA |
| author_facet | van Rheede, JJ Feldmann, LK Busch, JL Fleming, JE Mathiopoulou, V Denison, T Sharott, A Kühn, AA |
| author_sort | van Rheede, JJ |
| collection | OXFORD |
| description | Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson’s disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS). While beta fluctuations in PD patients are well characterized on shorter timescales, it is not known how beta activity evolves around the diurnal cycle, outside a clinical setting. Here, we obtained chronic recordings (34 ± 13 days) of subthalamic beta power in PD patients implanted with the Percept DBS device during high-frequency DBS and analysed their diurnal properties as well as sensitivity to artifacts. Time of day explained 41 ± 9% of the variance in beta power (p < 0.001 in all patients), with increased beta during the day and reduced beta at night. Certain movements affected LFP quality, which may have contributed to diurnal patterns in some patients. Future DBS algorithms may benefit from taking such diurnal and artifactual fluctuations in beta power into account. |
| first_indexed | 2024-03-07T07:12:25Z |
| format | Journal article |
| id | oxford-uuid:86adc672-e51e-489b-8fa1-9cd6a9995b21 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:12:25Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:86adc672-e51e-489b-8fa1-9cd6a9995b212022-07-12T12:19:54ZDiurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:86adc672-e51e-489b-8fa1-9cd6a9995b21EnglishSymplectic ElementsSpringer Nature2022van Rheede, JJFeldmann, LKBusch, JLFleming, JEMathiopoulou, VDenison, TSharott, AKühn, AABeta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson’s disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS). While beta fluctuations in PD patients are well characterized on shorter timescales, it is not known how beta activity evolves around the diurnal cycle, outside a clinical setting. Here, we obtained chronic recordings (34 ± 13 days) of subthalamic beta power in PD patients implanted with the Percept DBS device during high-frequency DBS and analysed their diurnal properties as well as sensitivity to artifacts. Time of day explained 41 ± 9% of the variance in beta power (p < 0.001 in all patients), with increased beta during the day and reduced beta at night. Certain movements affected LFP quality, which may have contributed to diurnal patterns in some patients. Future DBS algorithms may benefit from taking such diurnal and artifactual fluctuations in beta power into account. |
| spellingShingle | van Rheede, JJ Feldmann, LK Busch, JL Fleming, JE Mathiopoulou, V Denison, T Sharott, A Kühn, AA Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation |
| title | Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation |
| title_full | Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation |
| title_fullStr | Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation |
| title_full_unstemmed | Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation |
| title_short | Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation |
| title_sort | diurnal modulation of subthalamic beta oscillatory power in parkinson s disease patients during deep brain stimulation |
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