Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex.
We have physically mapped and cloned a 2.5-Mb chromosomal segment flanking the centromeric end of the major histocompatibility complex (MHC). We characterized in detail 27 YACs, 144 cosmids, 51 PACs, and 5 BACs, which will facilitate the complete genomic sequencing of this region of chromosome 6. Th...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1998
|
| _version_ | 1797079860513865728 |
|---|---|
| author | Tripodis, N Mason, R Humphray, S Davies, A Herberg, J Trowsdale, J Nizetic, D Senger, G Ragoussis, J |
| author_facet | Tripodis, N Mason, R Humphray, S Davies, A Herberg, J Trowsdale, J Nizetic, D Senger, G Ragoussis, J |
| author_sort | Tripodis, N |
| collection | OXFORD |
| description | We have physically mapped and cloned a 2.5-Mb chromosomal segment flanking the centromeric end of the major histocompatibility complex (MHC). We characterized in detail 27 YACs, 144 cosmids, 51 PACs, and 5 BACs, which will facilitate the complete genomic sequencing of this region of chromosome 6. The contig contains the genes encoding CSBP, p21, HSU09564 serine kinase, ZNF76, TCP-11, RPS10, HMGI(Y), BAK, and the human homolog of Tctex-7 (HSET). The GLO1 gene was mapped further centromeric in the 6p21.2-6p21.1 region toward TCTE-1. The gene order of the GLO1-HMGI(Y) segment in respect to the centromere is similar to the gene order in the mouse t-chromosome distal inversion, indicating that there is conservation in gene content but not gene order between humans and mice in this region. The close linkage of the BAK and CSBP genes to the MHC is of interest because of their possible involvement in autoimmune disease. |
| first_indexed | 2024-03-07T00:51:51Z |
| format | Journal article |
| id | oxford-uuid:86ae45dc-2e94-4d10-ae1a-38eeb6e7bcab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:51:51Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:86ae45dc-2e94-4d10-ae1a-38eeb6e7bcab2022-03-26T22:05:34ZPhysical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:86ae45dc-2e94-4d10-ae1a-38eeb6e7bcabEnglishSymplectic Elements at Oxford1998Tripodis, NMason, RHumphray, SDavies, AHerberg, JTrowsdale, JNizetic, DSenger, GRagoussis, JWe have physically mapped and cloned a 2.5-Mb chromosomal segment flanking the centromeric end of the major histocompatibility complex (MHC). We characterized in detail 27 YACs, 144 cosmids, 51 PACs, and 5 BACs, which will facilitate the complete genomic sequencing of this region of chromosome 6. The contig contains the genes encoding CSBP, p21, HSU09564 serine kinase, ZNF76, TCP-11, RPS10, HMGI(Y), BAK, and the human homolog of Tctex-7 (HSET). The GLO1 gene was mapped further centromeric in the 6p21.2-6p21.1 region toward TCTE-1. The gene order of the GLO1-HMGI(Y) segment in respect to the centromere is similar to the gene order in the mouse t-chromosome distal inversion, indicating that there is conservation in gene content but not gene order between humans and mice in this region. The close linkage of the BAK and CSBP genes to the MHC is of interest because of their possible involvement in autoimmune disease. |
| spellingShingle | Tripodis, N Mason, R Humphray, S Davies, A Herberg, J Trowsdale, J Nizetic, D Senger, G Ragoussis, J Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |
| title | Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |
| title_full | Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |
| title_fullStr | Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |
| title_full_unstemmed | Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |
| title_short | Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |
| title_sort | physical map of human 6p21 2 6p21 3 region flanking the centromeric end of the major histocompatibility complex |
| work_keys_str_mv | AT tripodisn physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT masonr physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT humphrays physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT daviesa physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT herbergj physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT trowsdalej physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT nizeticd physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT sengerg physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex AT ragoussisj physicalmapofhuman6p2126p213regionflankingthecentromericendofthemajorhistocompatibilitycomplex |