The role of ADP-ribosylation in regulating DNA double-strand break repair.
ADP-ribosylation is the post translational modification of proteins catalysed by ADP-ribosyltransferases (ARTs). ADP-ribosylation has been implicated in a wide variety of cellular processes including cell growth and differentiation, apoptosis and transcriptional regulation. Perhaps the best characte...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826283043383410688 |
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| author | Pears, C Couto, C Wang, H Borer, C Kiely, R Lakin, N |
| author_facet | Pears, C Couto, C Wang, H Borer, C Kiely, R Lakin, N |
| author_sort | Pears, C |
| collection | OXFORD |
| description | ADP-ribosylation is the post translational modification of proteins catalysed by ADP-ribosyltransferases (ARTs). ADP-ribosylation has been implicated in a wide variety of cellular processes including cell growth and differentiation, apoptosis and transcriptional regulation. Perhaps the best characterised role, however, is in DNA repair and genome stability where ADP-ribosylation promotes resolution of DNA single strand breaks. Although ADP-ribosylation also occurs at DNA double strand breaks (DSBs), which ARTs catalyse this reaction and the molecular basis of how this modification regulates their repair remains a matter of debate. Here we review recent advances in our understanding of how ADP-ribosylation regulates DSB repair. Specifically, we highlight studies using the genetic model organism Dictyostelium, in addition to vertebrate cells that identify a third ART that accelerates DSB repair by non-homologous end-joining through promoting the interaction of repair factors with DNA lesions. The implications of these data with regards to how ADP-ribosylation regulates DNA repair and genome stability are discussed. |
| first_indexed | 2024-03-07T00:52:58Z |
| format | Journal article |
| id | oxford-uuid:8705eb5c-dbe1-48c4-8688-c15594946e00 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:52:58Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:8705eb5c-dbe1-48c4-8688-c15594946e002022-03-26T22:08:02ZThe role of ADP-ribosylation in regulating DNA double-strand break repair.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8705eb5c-dbe1-48c4-8688-c15594946e00EnglishSymplectic Elements at Oxford2012Pears, CCouto, CWang, HBorer, CKiely, RLakin, NADP-ribosylation is the post translational modification of proteins catalysed by ADP-ribosyltransferases (ARTs). ADP-ribosylation has been implicated in a wide variety of cellular processes including cell growth and differentiation, apoptosis and transcriptional regulation. Perhaps the best characterised role, however, is in DNA repair and genome stability where ADP-ribosylation promotes resolution of DNA single strand breaks. Although ADP-ribosylation also occurs at DNA double strand breaks (DSBs), which ARTs catalyse this reaction and the molecular basis of how this modification regulates their repair remains a matter of debate. Here we review recent advances in our understanding of how ADP-ribosylation regulates DSB repair. Specifically, we highlight studies using the genetic model organism Dictyostelium, in addition to vertebrate cells that identify a third ART that accelerates DSB repair by non-homologous end-joining through promoting the interaction of repair factors with DNA lesions. The implications of these data with regards to how ADP-ribosylation regulates DNA repair and genome stability are discussed. |
| spellingShingle | Pears, C Couto, C Wang, H Borer, C Kiely, R Lakin, N The role of ADP-ribosylation in regulating DNA double-strand break repair. |
| title | The role of ADP-ribosylation in regulating DNA double-strand break repair. |
| title_full | The role of ADP-ribosylation in regulating DNA double-strand break repair. |
| title_fullStr | The role of ADP-ribosylation in regulating DNA double-strand break repair. |
| title_full_unstemmed | The role of ADP-ribosylation in regulating DNA double-strand break repair. |
| title_short | The role of ADP-ribosylation in regulating DNA double-strand break repair. |
| title_sort | role of adp ribosylation in regulating dna double strand break repair |
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