Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells.
Thymic epithelial cell differentiation, growth and function depend on the expression of the transcription factor Foxn1; however, its target genes have never been physically identified. Using static and inducible genetic model systems and chromatin studies, we developed a genome-wide map of direct Fo...
Main Authors: | Žuklys, S, Handel, A, Zhanybekova, S, Govani, F, Keller, M, Maio, S, Mayer, C, Teh, H, Hafen, K, Gallone, G, Barthlott, T, Ponting, C, Holländer, G |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Nature Publishing Group
2016
|
Similar Items
-
Foxn1 regulates in postnatal thymic epithelial cells key target genes essential for T cell development
by: Žuklys, S, et al.
Published: (2016) -
Comprehensively profiling the chromatin architecture of tissue restricted antigen expression in thymic epithelial cells over development
by: Handel, A, et al.
Published: (2018) -
Comment on "Identification of an intronic regulatory element necessary for tissue-specific expression of Foxn1 in thymic epithelial cells"
by: Handel, AE, et al.
Published: (2019) -
Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.
by: Jeker, LT, et al.
Published: (2008) -
Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development
by: Adam E. Handel, et al.
Published: (2018-09-01)