A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.

A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.

Many human T-cell responses specific for epitopes in Plasmodium falciparum have been described, but none has yet been shown to be predictive of protection against natural malaria infection. Here we report a peptide-specific T-cell assay that is strongly associated with protection of humans in The Ga...

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Bibliographic Details
Main Authors: Reece, W, Pinder, M, Gothard, P, Milligan, P, Bojang, K, Doherty, T, Plebanski, M, Akinwunmi, P, Everaere, S, Watkins, K, Voss, G, Tornieporth, N, Alloueche, A, Greenwood, B, Kester, K, McAdam, K, Cohen, J, Hill, A
Format: Journal article
Language:English
Published: 2004

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