New methods for the construction of C-18F bonds
<p>The main electrophilic source used in radiolabelling is [18F]F2, which is highly reactive, toxic and requires specialist equipment for safe handling. The Gouverneur group has initiated a research programme focused on the preparation of new stable and easy-to-handle N-18F reagents. In the de...
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2014
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author | Stenhagen, I |
author2 | Gouverneur, V |
author_facet | Gouverneur, V Stenhagen, I |
author_sort | Stenhagen, I |
collection | OXFORD |
description | <p>The main electrophilic source used in radiolabelling is [18F]F2, which is highly reactive, toxic and requires specialist equipment for safe handling. The Gouverneur group has initiated a research programme focused on the preparation of new stable and easy-to-handle N-18F reagents. In the development of [18F]radiolabelling reactions it would be extremely valuable to develop a library of selective N-18F reagents possessing reactivity tailored to the desired chemical transformation. The aim of this thesis is to further assess the scope of electrophilic N- 18F reagents in new transformations for the construction of C-18F bonds.</p> |
first_indexed | 2024-03-07T08:18:51Z |
format | Thesis |
id | oxford-uuid:871a7e8c-a4d3-4acb-a25d-5946dec2f44d |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T08:18:51Z |
publishDate | 2014 |
record_format | dspace |
spelling | oxford-uuid:871a7e8c-a4d3-4acb-a25d-5946dec2f44d2024-01-16T16:04:02ZNew methods for the construction of C-18F bondsThesishttp://purl.org/coar/resource_type/c_db06uuid:871a7e8c-a4d3-4acb-a25d-5946dec2f44dOrganic synthesisOrganometallic ChemistryOrganic chemistryEnglishOxford University Research Archive - Valet2014Stenhagen, IGouverneur, V<p>The main electrophilic source used in radiolabelling is [18F]F2, which is highly reactive, toxic and requires specialist equipment for safe handling. The Gouverneur group has initiated a research programme focused on the preparation of new stable and easy-to-handle N-18F reagents. In the development of [18F]radiolabelling reactions it would be extremely valuable to develop a library of selective N-18F reagents possessing reactivity tailored to the desired chemical transformation. The aim of this thesis is to further assess the scope of electrophilic N- 18F reagents in new transformations for the construction of C-18F bonds.</p> |
spellingShingle | Organic synthesis Organometallic Chemistry Organic chemistry Stenhagen, I New methods for the construction of C-18F bonds |
title | New methods for the construction of C-18F bonds |
title_full | New methods for the construction of C-18F bonds |
title_fullStr | New methods for the construction of C-18F bonds |
title_full_unstemmed | New methods for the construction of C-18F bonds |
title_short | New methods for the construction of C-18F bonds |
title_sort | new methods for the construction of c 18f bonds |
topic | Organic synthesis Organometallic Chemistry Organic chemistry |
work_keys_str_mv | AT stenhageni newmethodsfortheconstructionofc18fbonds |