New methods for the construction of C-18F bonds

<p>The main electrophilic source used in radiolabelling is [18F]F2, which is highly reactive, toxic and requires specialist equipment for safe handling. The Gouverneur group has initiated a research programme focused on the preparation of new stable and easy-to-handle N-18F reagents. In the de...

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Détails bibliographiques
Auteur principal: Stenhagen, I
Autres auteurs: Gouverneur, V
Format: Thèse
Langue:English
Publié: 2014
Sujets:
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author Stenhagen, I
author2 Gouverneur, V
author_facet Gouverneur, V
Stenhagen, I
author_sort Stenhagen, I
collection OXFORD
description <p>The main electrophilic source used in radiolabelling is [18F]F2, which is highly reactive, toxic and requires specialist equipment for safe handling. The Gouverneur group has initiated a research programme focused on the preparation of new stable and easy-to-handle N-18F reagents. In the development of [18F]radiolabelling reactions it would be extremely valuable to develop a library of selective N-18F reagents possessing reactivity tailored to the desired chemical transformation. The aim of this thesis is to further assess the scope of electrophilic N- 18F reagents in new transformations for the construction of C-18F bonds.</p>
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spelling oxford-uuid:871a7e8c-a4d3-4acb-a25d-5946dec2f44d2024-01-16T16:04:02ZNew methods for the construction of C-18F bondsThesishttp://purl.org/coar/resource_type/c_db06uuid:871a7e8c-a4d3-4acb-a25d-5946dec2f44dOrganic synthesisOrganometallic ChemistryOrganic chemistryEnglishOxford University Research Archive - Valet2014Stenhagen, IGouverneur, V<p>The main electrophilic source used in radiolabelling is [18F]F2, which is highly reactive, toxic and requires specialist equipment for safe handling. The Gouverneur group has initiated a research programme focused on the preparation of new stable and easy-to-handle N-18F reagents. In the development of [18F]radiolabelling reactions it would be extremely valuable to develop a library of selective N-18F reagents possessing reactivity tailored to the desired chemical transformation. The aim of this thesis is to further assess the scope of electrophilic N- 18F reagents in new transformations for the construction of C-18F bonds.</p>
spellingShingle Organic synthesis
Organometallic Chemistry
Organic chemistry
Stenhagen, I
New methods for the construction of C-18F bonds
title New methods for the construction of C-18F bonds
title_full New methods for the construction of C-18F bonds
title_fullStr New methods for the construction of C-18F bonds
title_full_unstemmed New methods for the construction of C-18F bonds
title_short New methods for the construction of C-18F bonds
title_sort new methods for the construction of c 18f bonds
topic Organic synthesis
Organometallic Chemistry
Organic chemistry
work_keys_str_mv AT stenhageni newmethodsfortheconstructionofc18fbonds