Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice.

Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice.

Interaction between the proximal (-378) promoter and the far upstream (-20 kb) enhancer is essential for tissue-specific expression of the human alpha2(I) collagen gene (COL1A2) in transgenic mice. Previous in vitro studies have shown that three Sp1 binding sites (around -300) are part of a cytokine...

Полное описание

Библиографические подробности
Главные авторы:	Tanaka, S, Antoniv, T, Liu, K, Wang, L, Wells, D, Ramirez, F, Bou-Gharios, G
Формат:	Journal article
Язык:	English
Опубликовано:	2004

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