Substituted pyrroles via olefin cross-metathesis.
Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797079970324938752 |
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| author | Donohoe, T Race, N Bower, J Callens, C |
| author_facet | Donohoe, T Race, N Bower, J Callens, C |
| author_sort | Donohoe, T |
| collection | OXFORD |
| description | Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin. |
| first_indexed | 2024-03-07T00:53:30Z |
| format | Journal article |
| id | oxford-uuid:873418f7-3406-493b-8e27-31257bf8c02a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:53:30Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:873418f7-3406-493b-8e27-31257bf8c02a2022-03-26T22:09:10ZSubstituted pyrroles via olefin cross-metathesis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:873418f7-3406-493b-8e27-31257bf8c02aEnglishSymplectic Elements at Oxford2010Donohoe, TRace, NBower, JCallens, COlefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin. |
| spellingShingle | Donohoe, T Race, N Bower, J Callens, C Substituted pyrroles via olefin cross-metathesis. |
| title | Substituted pyrroles via olefin cross-metathesis. |
| title_full | Substituted pyrroles via olefin cross-metathesis. |
| title_fullStr | Substituted pyrroles via olefin cross-metathesis. |
| title_full_unstemmed | Substituted pyrroles via olefin cross-metathesis. |
| title_short | Substituted pyrroles via olefin cross-metathesis. |
| title_sort | substituted pyrroles via olefin cross metathesis |
| work_keys_str_mv | AT donohoet substitutedpyrrolesviaolefincrossmetathesis AT racen substitutedpyrrolesviaolefincrossmetathesis AT bowerj substitutedpyrrolesviaolefincrossmetathesis AT callensc substitutedpyrrolesviaolefincrossmetathesis |