Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate

Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate

Purpose: To demonstrate the feasibility of mapping intracellular pH within the in vivo rodent heart. Introduction: Alterations in cardiac acid-base balance can lead to acute contractile depression and alterations in Ca2+ signalling. The transient reduction in ATP consumption and cardiac contractili...

Bibliografski detalji
Glavni autori:	Lau, A, Miller, J, Tyler, D
Daljnji autori:	Ernst, T
Format:	Journal article
Izdano:	Wiley 2016

Slični predmeti

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo.
od: Chen, A, i dr.
Izdano: (2012)

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
od: Schroeder, M, i dr.
Izdano: (2008)

Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart.
od: Lau, A, i dr.
Izdano: (2010)

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2- C ]pyruvate in vivo
od: Chen, A, i dr.
Izdano: (2012)

Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.
od: Schroeder, M, i dr.
Izdano: (2013)

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study.
od: Schroeder, M, i dr.
Izdano: (2010)

13C MRI of hyperpolarized pyruvate at 120 µT
od: Nicolas Kempf, i dr.
Izdano: (2024-02-01)

Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid
od: Stephan Düwel, i dr.
Izdano: (2017-05-01)

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1–13C]pyruvate in vivo
od: Keilian MacCulloch, i dr.
Izdano: (2023-12-01)

Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC
od: Elisabeth Bliemsrieder, i dr.
Izdano: (2021-01-01)

In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate.
od: Hu, S, i dr.
Izdano: (2009)

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain
od: Healicon, R, i dr.
Izdano: (2022)

Assessment of Metformin Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.
od: Lewis, A, i dr.
Izdano: (2016)

Author Correction: Hyperpolarized 13C pyruvate magnetic resonance spectroscopy for in vivo metabolic phenotyping of rat HCC
od: Elisabeth Bliemsrieder, i dr.
Izdano: (2021-05-01)

Potential clinical roles for metabolic imaging with hyperpolarized [1-13C]pyruvate
od: Kevin eBrindle, i dr.
Izdano: (2016-03-01)

Hyperpolarized ketone body metabolism in the rat heart
od: Miller, J, i dr.
Izdano: (2018)

Mutual-information based optimal experimental design for hyperpolarized $$^{13}$$ 13 C-pyruvate MRI
od: Prashant K. Jha, i dr.
Izdano: (2023-10-01)

Non-invasive in vivo assessment of cardiac metabolism in the healthy and diabetic human heart using hyperpolarized 13C MRI
od: Rider, OJ, i dr.
Izdano: (2020)

Segmental analysis of cardiac metabolism by hyperpolarized [1-13C] pyruvate: an in-vivo 3D MRI study in pigs
od: Positano Vincenzo, i dr.
Izdano: (2012-02-01)

Cardiac pH-Imaging With Hyperpolarized MRI
od: Nikolaj Bøgh, i dr.
Izdano: (2020-11-01)

Non-invasive assessment of metformin induced changes in cardiac and hepatic redox state using hyperpolarized [1–13C] pyruvate
od: Lewis, A, i dr.
Izdano: (2016)

Metabolite-Specific Echo-Planar Imaging of Hyperpolarized [1-<sup>13</sup>C]Pyruvate at 4.7 T
od: Tyler Blazey, i dr.
Izdano: (2021-09-01)

Intracellular pH regulation in heart.
od: Vaughan-Jones, R, i dr.
Izdano: (2009)

Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage
od: Brian T. Chung, i dr.
Izdano: (2023-10-01)

Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-13C] Pyruvate
od: Mukundan Ragavan, i dr.
Izdano: (2022-02-01)

Hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure
od: Steen Hylgaard Joergensen, i dr.
Izdano: (2024-01-01)

Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR
od: Marco-Rius, I, i dr.
Izdano: (2020)

PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI
od: Alexandra Svyatova, i dr.
Izdano: (2021-03-01)

Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging
od: Steen Hylgaard Joergensen, i dr.
Izdano: (2022-06-01)

Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer
od: Ivan de Kouchkovsky, i dr.
Izdano: (2024-12-01)

Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer
od: Obaid Mohiuddin, i dr.
Izdano: (2024-10-01)

Detection of 3D Cardiac metabolism after injection of hyperpolarized [1-13C]pyruvate
od: Landini Luigi, i dr.
Izdano: (2011-02-01)

Determination of cardiac metabolism in vivo with hyperpolarized carbon-13 magnetic resonance
od: Schroeder, M, i dr.
Izdano: (2007)

Myocardial metabolic flexibility following ketone infusion demonstrated by hyperpolarized [2-13C]pyruvate MRS in pigs
od: Sabrina Kahina Bech, i dr.
Izdano: (2025-02-01)

In Vivo Assessment of Metabolic Abnormality in Alport Syndrome Using Hyperpolarized [1-<sup>13</sup>C] Pyruvate MR Spectroscopic Imaging
od: Nguyen-Trong Nguyen, i dr.
Izdano: (2021-04-01)

Quantifying normal human brain metabolism using hyperpolarized [1–13C]pyruvate and magnetic resonance imaging
od: Grist, JT, i dr.
Izdano: (2019)

Hyperpolarized magnetic resonance shows that the antiischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved postischemic function in the diabetic heart
od: Savic, D, i dr.
Izdano: (2021)

Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors
od: Changhua Mu, i dr.
Izdano: (2024-09-01)

Quantification of Abnormal Metabolism in Hypertrophic Cardiomyopathy Patients Using Hyperpolarized [1-13c]-pyruvate MRI
od: Avantika Sinha, MSc, i dr.
Izdano: (2024-01-01)

3D cardiac Chemical Shift Imaging of [1-13C] hyperpolarized acetate and pyruvate in pigs
od: Menichetti Luca, i dr.
Izdano: (2013-01-01)