Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants.
Red blood cells that are infected with the malaria parasite Plasmodium falciparum express new antigens on their surface. In a study of these antigens in the erythrocytes of naturally infected children in the Gambia, an antibody-mediated agglutination assay revealed an extreme degree of antigenic div...
| Κύριοι συγγραφείς: | , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
1986
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| _version_ | 1826283121089183744 |
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| author | Marsh, K Howard, R |
| author_facet | Marsh, K Howard, R |
| author_sort | Marsh, K |
| collection | OXFORD |
| description | Red blood cells that are infected with the malaria parasite Plasmodium falciparum express new antigens on their surface. In a study of these antigens in the erythrocytes of naturally infected children in the Gambia, an antibody-mediated agglutination assay revealed an extreme degree of antigenic diversity. Serum samples from each of ten children in the convalescent stage of malaria infection reacted with infected cells from the same child but generally not with infected cells from the other children. The Gambian children's erythrocytes also expressed shared determinants: sera from Gambian adults often reacted with the surface of infected cells from all of the children and were shown by adsorption and elution experiments to contain antibodies that recognized several isolates. Conserved determinants exposed on infected erythrocytes may be important for development of antimalarial immunity either naturally or through vaccination. |
| first_indexed | 2024-03-07T00:54:09Z |
| format | Journal article |
| id | oxford-uuid:8772771a-7389-48d6-8db2-e0b8cf454d83 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:54:09Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:8772771a-7389-48d6-8db2-e0b8cf454d832022-03-26T22:10:43ZAntigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8772771a-7389-48d6-8db2-e0b8cf454d83EnglishSymplectic Elements at Oxford1986Marsh, KHoward, RRed blood cells that are infected with the malaria parasite Plasmodium falciparum express new antigens on their surface. In a study of these antigens in the erythrocytes of naturally infected children in the Gambia, an antibody-mediated agglutination assay revealed an extreme degree of antigenic diversity. Serum samples from each of ten children in the convalescent stage of malaria infection reacted with infected cells from the same child but generally not with infected cells from the other children. The Gambian children's erythrocytes also expressed shared determinants: sera from Gambian adults often reacted with the surface of infected cells from all of the children and were shown by adsorption and elution experiments to contain antibodies that recognized several isolates. Conserved determinants exposed on infected erythrocytes may be important for development of antimalarial immunity either naturally or through vaccination. |
| spellingShingle | Marsh, K Howard, R Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. |
| title | Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. |
| title_full | Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. |
| title_fullStr | Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. |
| title_full_unstemmed | Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. |
| title_short | Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. |
| title_sort | antigens induced on erythrocytes by p falciparum expression of diverse and conserved determinants |
| work_keys_str_mv | AT marshk antigensinducedonerythrocytesbypfalciparumexpressionofdiverseandconserveddeterminants AT howardr antigensinducedonerythrocytesbypfalciparumexpressionofdiverseandconserveddeterminants |