Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells.
BY55 is a human cell surface molecule whose expression is restricted to NK cells, a subset of circulating CD8+ T lymphocytes, and all intestinal intraepithelial T lymphocytes. Here, we report that BY55 is a novel NK receptor showing broad specificity for both classical and nonclassical MHC class I m...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1826283125287682048 |
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| author | Agrawal, S Marquet, J Freeman, G Tawab, A Bouteiller, P Roth, P Bolton, W Ogg, G Boumsell, L Bensussan, A |
| author_facet | Agrawal, S Marquet, J Freeman, G Tawab, A Bouteiller, P Roth, P Bolton, W Ogg, G Boumsell, L Bensussan, A |
| author_sort | Agrawal, S |
| collection | OXFORD |
| description | BY55 is a human cell surface molecule whose expression is restricted to NK cells, a subset of circulating CD8+ T lymphocytes, and all intestinal intraepithelial T lymphocytes. Here, we report that BY55 is a novel NK receptor showing broad specificity for both classical and nonclassical MHC class I molecules, and that optimal binding requires a prior aggregation of MHC class I complexes. Using BY55 transfectants, we have identified functional consequences of MHC class I/ligand interactions for the class I-bearing cell. The triggering of MHC class I molecules on human T cell clones by BY55 delivered a potent proliferative signal in the presence of soluble CD3 mAb. The costimulatory signal provided by MHC class I ligation was only seen in activated, and not resting, peripheral blood T cells. This observation represents an additional and/or alternative pathway to CD28 costimulation and may be of particular relevance in memory T cells lacking CD28, such as intestinal intraepithelial T lymphocytes, which are CD28- but BY55+. |
| first_indexed | 2024-03-07T00:54:13Z |
| format | Journal article |
| id | oxford-uuid:8777b4de-4a2a-4e77-baf2-e89569de7b67 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:54:13Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:8777b4de-4a2a-4e77-baf2-e89569de7b672022-03-26T22:10:52ZCutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:8777b4de-4a2a-4e77-baf2-e89569de7b67EnglishSymplectic Elements at Oxford1999Agrawal, SMarquet, JFreeman, GTawab, ABouteiller, PRoth, PBolton, WOgg, GBoumsell, LBensussan, ABY55 is a human cell surface molecule whose expression is restricted to NK cells, a subset of circulating CD8+ T lymphocytes, and all intestinal intraepithelial T lymphocytes. Here, we report that BY55 is a novel NK receptor showing broad specificity for both classical and nonclassical MHC class I molecules, and that optimal binding requires a prior aggregation of MHC class I complexes. Using BY55 transfectants, we have identified functional consequences of MHC class I/ligand interactions for the class I-bearing cell. The triggering of MHC class I molecules on human T cell clones by BY55 delivered a potent proliferative signal in the presence of soluble CD3 mAb. The costimulatory signal provided by MHC class I ligation was only seen in activated, and not resting, peripheral blood T cells. This observation represents an additional and/or alternative pathway to CD28 costimulation and may be of particular relevance in memory T cells lacking CD28, such as intestinal intraepithelial T lymphocytes, which are CD28- but BY55+. |
| spellingShingle | Agrawal, S Marquet, J Freeman, G Tawab, A Bouteiller, P Roth, P Bolton, W Ogg, G Boumsell, L Bensussan, A Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. |
| title | Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. |
| title_full | Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. |
| title_fullStr | Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. |
| title_full_unstemmed | Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. |
| title_short | Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. |
| title_sort | cutting edge mhc class i triggering by a novel cell surface ligand costimulates proliferation of activated human t cells |
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